Catalysis of a new ribose carbon-insertion reaction by the molybdenum cofactor biosynthetic enzyme MoaA

Angad P. Mehta; Jeremiah W. Hanes; Sameh H. Abdelwahed; David G. Hilmey; Petra Hänzelmann; Tadhg P. Begley

doi:10.1021/bi3016026

Catalysis of a new ribose carbon-insertion reaction by the molybdenum cofactor biosynthetic enzyme MoaA

Angad P. Mehta, Jeremiah W. Hanes, Sameh H. Abdelwahed, David G. Hilmey, Petra Hänzelmann, Tadhg P. Begley

Research output: Contribution to journal › Article › peer-review

Abstract

MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in molybdopterin biosynthesis. This reaction involves a complex rearrangement in which C8 of guanosine triphosphate is inserted between C2′ and C3′ of the ribose. This study identifies the site of initial hydrogen atom abstraction by the adenosyl radical and advances a mechanistic proposal for this unprecedented reaction.

Original language	English (US)
Pages (from-to)	1134-1136
Number of pages	3
Journal	Biochemistry
Volume	52
Issue number	7
DOIs	https://doi.org/10.1021/bi3016026
State	Published - Feb 19 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry

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10.1021/bi3016026

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abstract = "MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in molybdopterin biosynthesis. This reaction involves a complex rearrangement in which C8 of guanosine triphosphate is inserted between C2′ and C3′ of the ribose. This study identifies the site of initial hydrogen atom abstraction by the adenosyl radical and advances a mechanistic proposal for this unprecedented reaction.",

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AU - Mehta, Angad P.

AU - Hanes, Jeremiah W.

AU - Abdelwahed, Sameh H.

AU - Hilmey, David G.

AU - Hänzelmann, Petra

AU - Begley, Tadhg P.

PY - 2013/2/19

Y1 - 2013/2/19

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AB - MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in molybdopterin biosynthesis. This reaction involves a complex rearrangement in which C8 of guanosine triphosphate is inserted between C2′ and C3′ of the ribose. This study identifies the site of initial hydrogen atom abstraction by the adenosyl radical and advances a mechanistic proposal for this unprecedented reaction.

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Catalysis of a new ribose carbon-insertion reaction by the molybdenum cofactor biosynthetic enzyme MoaA

Abstract

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