TY - JOUR
T1 - Casein Kinase II
T2 - An attractive target for anti-cancer drug design
AU - Hanif, Ismail Muhamad
AU - Hanif, Ibrahim Muhammad
AU - Shazib, Muhammad Ali
AU - Ahmad, Kashif Adil
AU - Pervaiz, Shazib
N1 - Funding Information:
SP is supported by research grants from the National Medical Research Council (NMRC), Biomedical Research Council (BMRC), Singapore Cancer Syndicate (SCS), Ministry of Education Tier-2 funding (MOE Tier-2), Duke-NUS Cancer and Stem Cell Biology Program (CSCB), Experimental Therapeutics Program of the Cancer Science Institute (ET-CSI), Singapore. The authors wish to thank Dr. Nafis Muhamad Hanif for her contributions in the preparation of this manuscript.
PY - 2010/10
Y1 - 2010/10
N2 - Casein Kinase II (CK2) is a ubiquitous serine/threonine kinase that is highly conserved in eukaryotic cells. CK2 has been shown to impact cell growth and proliferation, as numerous growth-related proteins are substrates of CK2. More importantly, experimental evidence linking increased expression and activity of CK2 to human cancers underscores the relevance of CK2 biology to cellular transformation and carcinogenesis. Due to the critical regulatory role CK2 plays in cell fate determination in cancer cells, there is a tremendous interest in the development of CK2-specific therapies. Supporting this, recent reports have demonstrated that genetic manipulation of CK2 expression as well as pharmacological inhibition of its enzymatic activity sensitizes cancers to apoptotic stimuli. Here we provide a succinct account of the biology of CK2, its cellular substrates, its pro-survival and pro-proliferation activity, and highlight evidence for its involvement in human cancer.
AB - Casein Kinase II (CK2) is a ubiquitous serine/threonine kinase that is highly conserved in eukaryotic cells. CK2 has been shown to impact cell growth and proliferation, as numerous growth-related proteins are substrates of CK2. More importantly, experimental evidence linking increased expression and activity of CK2 to human cancers underscores the relevance of CK2 biology to cellular transformation and carcinogenesis. Due to the critical regulatory role CK2 plays in cell fate determination in cancer cells, there is a tremendous interest in the development of CK2-specific therapies. Supporting this, recent reports have demonstrated that genetic manipulation of CK2 expression as well as pharmacological inhibition of its enzymatic activity sensitizes cancers to apoptotic stimuli. Here we provide a succinct account of the biology of CK2, its cellular substrates, its pro-survival and pro-proliferation activity, and highlight evidence for its involvement in human cancer.
KW - Apoptosis
KW - Cancer
KW - Proliferation
KW - Protein Kinase CK2
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U2 - 10.1016/j.biocel.2010.06.010
DO - 10.1016/j.biocel.2010.06.010
M3 - Short survey
C2 - 20558317
AN - SCOPUS:77956188008
SN - 1357-2725
VL - 42
SP - 1602
EP - 1605
JO - International Journal of Biochemistry
JF - International Journal of Biochemistry
IS - 10
ER -