Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States

Chenghuai Yang, Leyi Wang, Kent Schwartz, Eric Burrough, Jennifer Groeltz-Thrush, Qi Chen, Ying Zheng, Huigang Shen, Ganwu Li

Research output: Contribution to journalArticlepeer-review

Abstract

Nodaviruses are small bisegmented RNA viruses belonging to the family Nodaviridae. Nodaviruses have been identified in different hosts, including insects, fishes, shrimps, prawns, dogs, and bats. A novel porcine nodavirus was first identified in the United States by applying next-generation sequencing on brain tissues of pigs with neurological signs, including uncontrollable shaking. RNA1 of the porcine nodavirus had the highest nucleotide identity (51.1%) to the Flock House virus, whereas its RNA2 shared the highest nucleotide identity (48%) with the RNA2 segment of caninovirus (Canine nodavirus). Genetic characterization classified porcine nodavirus as a new species under the genus Alphanodavirus. Further studies are needed to understand the pathogenicity and clinical impacts of this virus.
Original languageEnglish (US)
Article number73
JournalViruses
Volume13
Issue number1
DOIs
StatePublished - Jan 7 2021

Keywords

  • porcine nodavirus
  • United States
  • characterization
  • detection
  • genome

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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