Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States

Chenghuai Yang, Leyi Wang, Kent Schwartz, Eric Burrough, Jennifer Groeltz-Thrush, Qi Chen, Ying Zheng, Huigang Shen, Ganwu Li

Research output: Contribution to journalArticlepeer-review

Abstract

Nodaviruses are small bisegmented RNA viruses belonging to the family Nodaviridae. Nodaviruses have been identified in different hosts, including insects, fishes, shrimps, prawns, dogs, and bats. A novel porcine nodavirus was first identified in the United States by applying next-generation sequencing on brain tissues of pigs with neurological signs, including uncontrollable shaking. RNA1 of the porcine nodavirus had the highest nucleotide identity (51.1%) to the Flock House virus, whereas its RNA2 shared the highest nucleotide identity (48%) with the RNA2 segment of caninovirus (Canine nodavirus). Genetic characterization classified porcine nodavirus as a new species under the genus Alphanodavirus. Further studies are needed to understand the pathogenicity and clinical impacts of this virus.
Original languageEnglish (US)
JournalViruses
Volume13
Issue number1
DOIs
StatePublished - 2021

Keywords

  • porcine nodavirus
  • United States
  • characterization
  • detection
  • genome

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