TY - JOUR
T1 - Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties
AU - Song, Guosheng
AU - Kenney, Michael
AU - Chen, Yun Sheng
AU - Zheng, Xianchuang
AU - Deng, Yong
AU - Chen, Zhuo
AU - Wang, Shan X.
AU - Gambhir, Sanjiv Sam
AU - Dai, Hongjie
AU - Rao, Jianghong
N1 - Funding Information:
We acknowledge the use of Stanford Centre for Innovation in In-Vivo Imaging (SCI3) Core Facility. This work was supported by the Stanford University National Cancer Institute (CCNE-T grant no. U54CA199075).
Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - The low magnetic saturation of iron oxide nanoparticles, which are developed primarily as contrast agents for magnetic resonance imaging, limits the sensitivity of their detection using magnetic particle imaging (MPI). Here, we show that FeCo nanoparticles that have a core diameter of 10 nm and bear a graphitic carbon shell decorated with poly(ethylene glycol) provide an MPI signal intensity that is sixfold and fifteenfold higher than the signals from the superparamagnetic iron oxide tracers VivoTrax and Feraheme, respectively, at the same molar concentration of iron. We also show that the nanoparticles have photothermal and magnetothermal properties and can therefore be used for tumour ablation in mice, and that they have high optical absorbance in a broad near-infrared region spectral range (wavelength, 700–1,200 nm), making them suitable as tracers for photoacoustic imaging. As sensitive multifunctional and multimodal imaging tracers, carbon-coated FeCo nanoparticles may confer advantages in cancer imaging and hyperthermia therapy.
AB - The low magnetic saturation of iron oxide nanoparticles, which are developed primarily as contrast agents for magnetic resonance imaging, limits the sensitivity of their detection using magnetic particle imaging (MPI). Here, we show that FeCo nanoparticles that have a core diameter of 10 nm and bear a graphitic carbon shell decorated with poly(ethylene glycol) provide an MPI signal intensity that is sixfold and fifteenfold higher than the signals from the superparamagnetic iron oxide tracers VivoTrax and Feraheme, respectively, at the same molar concentration of iron. We also show that the nanoparticles have photothermal and magnetothermal properties and can therefore be used for tumour ablation in mice, and that they have high optical absorbance in a broad near-infrared region spectral range (wavelength, 700–1,200 nm), making them suitable as tracers for photoacoustic imaging. As sensitive multifunctional and multimodal imaging tracers, carbon-coated FeCo nanoparticles may confer advantages in cancer imaging and hyperthermia therapy.
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U2 - 10.1038/s41551-019-0506-0
DO - 10.1038/s41551-019-0506-0
M3 - Article
C2 - 32015409
AN - SCOPUS:85078888844
SN - 2157-846X
VL - 4
SP - 325
EP - 334
JO - Nature Biomedical Engineering
JF - Nature Biomedical Engineering
IS - 3
ER -