Carbohydrate metabolism and pathogenesis of diabetes mellitus in dogs and cats

Research output: Chapter in Book/Report/Conference proceedingChapter


Diabetes mellitus (DM) is a common disease in dogs and cats and its prevalence is increasing in both species, probably due to an increase in obesity, although only in cats has obesity been clearly identified as a major risk factor for diabetes. While the classification of diabetes in dogs and cats has been modeled after that of humans, many aspects are different. Autoimmune destruction of beta cells, a feature of type 1 DM in people, is common in dogs; however, in contrast to what is seen in people, the disease occurs in older dogs. Diabetes also occurs in older cats but islet pathology in those species is characterized by the presence of amyloid, the hallmark of type 2 DM. Despite being overweight or obese, most naive diabetic cats, contrary to type 2 diabetic humans, present with low insulin concentrations. The physiology of carbohydrate metabolism and pathogenesis of diabetes, including histopathologic findings, in dogs and cats are discussed in this chapter.

Original languageEnglish (US)
Title of host publicationGlucose Homeostatis and the Pathogenesis of Diabetes Mellitus
PublisherElsevier B.V.
Number of pages36
ISBN (Print)9780128001011
StatePublished - 2014

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173


  • Adipokines
  • Amyloid
  • Autoimmune
  • Cat
  • Dog
  • Glucose tolerance
  • Inflammation
  • Insulin resistance
  • Islet amyloid polypeptide
  • Obesity

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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