Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology

Hui Fang; Ki Jun Yu; Christopher Gloschat; Zijian Yang; Enming Song; Chia Han Chiang; Jianing Zhao; Sang Min Won; Siyi Xu; Michael Trumpis; Yiding Zhong; Seung Won Han; Yeguang Xue; Dong Xu; Seo Woo Choi; Gert Cauwenberghs; Matthew Kay; Yonggang Huang; Jonathan Viventi; Igor R. Efimov; John A. Rogers

doi:10.1038/s41551-017-0038

Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology

Hui Fang, Ki Jun Yu, Christopher Gloschat, Zijian Yang, Enming Song, Chia Han Chiang, Jianing Zhao, Sang Min Won, Siyi Xu, Michael Trumpis, Yiding Zhong, Seung Won Han, Yeguang Xue, Dong Xu, Seo Woo Choi, Gert Cauwenberghs, Matthew Kay, Yonggang Huang, Jonathan Viventi, Igor R. EfimovJohn A. Rogers

Research output: Contribution to journal › Article › peer-review

Abstract

Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying array of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, without the need for direct metal contact. The resulting current-leakage levels and operational lifetimes are, respectively, four orders of magnitude smaller and between two and three orders of magnitude longer than those of other flexible-electronics technologies. Systematic electro-physiological studies with normal, paced and arrhythmic conditions in Langendorff hearts highlight the capabilities of the capacitive-coupling approach. These advances provide realistic pathways towards the broad applicability of biocompatible, flexible electronic implants.

Original language	English (US)
Article number	0038
Journal	Nature biomedical engineering
Volume	1
Issue number	3
DOIs	https://doi.org/10.1038/s41551-017-0038
State	Published - Mar 9 2017

ASJC Scopus subject areas

Biotechnology
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Computer Science Applications

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10.1038/s41551-017-0038

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Fang, H., Yu, K. J., Gloschat, C., Yang, Z., Song, E., Chiang, C. H., Zhao, J., Won, S. M., Xu, S., Trumpis, M., Zhong, Y., Han, S. W., Xue, Y., Xu, D., Choi, S. W., Cauwenberghs, G., Kay, M., Huang, Y., Viventi, J., ... Rogers, J. A. (2017). Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology. Nature biomedical engineering, 1(3), Article 0038. https://doi.org/10.1038/s41551-017-0038

Fang, H, Yu, KJ, Gloschat, C, Yang, Z, Song, E, Chiang, CH, Zhao, J, Won, SM, Xu, S, Trumpis, M, Zhong, Y, Han, SW, Xue, Y, Xu, D, Choi, SW, Cauwenberghs, G, Kay, M, Huang, Y, Viventi, J, Efimov, IR & Rogers, JA 2017, 'Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology', Nature biomedical engineering, vol. 1, no. 3, 0038. https://doi.org/10.1038/s41551-017-0038

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abstract = "Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying array of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, without the need for direct metal contact. The resulting current-leakage levels and operational lifetimes are, respectively, four orders of magnitude smaller and between two and three orders of magnitude longer than those of other flexible-electronics technologies. Systematic electro-physiological studies with normal, paced and arrhythmic conditions in Langendorff hearts highlight the capabilities of the capacitive-coupling approach. These advances provide realistic pathways towards the broad applicability of biocompatible, flexible electronic implants.",

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AU - Zhao, Jianing

AU - Won, Sang Min

AU - Xu, Siyi

AU - Trumpis, Michael

AU - Zhong, Yiding

AU - Han, Seung Won

AU - Xue, Yeguang

AU - Xu, Dong

AU - Choi, Seo Woo

AU - Cauwenberghs, Gert

AU - Kay, Matthew

AU - Huang, Yonggang

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AU - Efimov, Igor R.

AU - Rogers, John A.

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N2 - Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying array of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, without the need for direct metal contact. The resulting current-leakage levels and operational lifetimes are, respectively, four orders of magnitude smaller and between two and three orders of magnitude longer than those of other flexible-electronics technologies. Systematic electro-physiological studies with normal, paced and arrhythmic conditions in Langendorff hearts highlight the capabilities of the capacitive-coupling approach. These advances provide realistic pathways towards the broad applicability of biocompatible, flexible electronic implants.

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Capacitively coupled arrays of multiplexed flexible silicon transistors for long-term cardiac electrophysiology

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