TY - JOUR
T1 - Cantilever-based sensor for the detection of different chromophore isomers
AU - Flores-Perez, Rosangelly
AU - Gupta, Amit K.
AU - Bashir, Rashid
AU - Ivanisevic, Albena
PY - 2007/6/15
Y1 - 2007/6/15
N2 - We report the use of microcantilevers (MCs) for the detection of three retinoid isomers: 9-cis-retinal, 13-cis-retinal and all-trans-retinal. Detection of synthetic and natural retinoids in topical cosmetic products is important, and their presence can be used to predict reactions with the skin surface. In this study the MC surfaces were functionalized in order to promote the formation of covalent bonds with the chromophores. The lowest mass shift we detected with the functionalized MCs was 1.2 ppt, which is in the range needed by the cosmetics industry. Our results indicate that properly designed and functionalized microcantilevers can be used to construct economical, fast, and sensitive sensors for quality control in cosmetics.
AB - We report the use of microcantilevers (MCs) for the detection of three retinoid isomers: 9-cis-retinal, 13-cis-retinal and all-trans-retinal. Detection of synthetic and natural retinoids in topical cosmetic products is important, and their presence can be used to predict reactions with the skin surface. In this study the MC surfaces were functionalized in order to promote the formation of covalent bonds with the chromophores. The lowest mass shift we detected with the functionalized MCs was 1.2 ppt, which is in the range needed by the cosmetics industry. Our results indicate that properly designed and functionalized microcantilevers can be used to construct economical, fast, and sensitive sensors for quality control in cosmetics.
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U2 - 10.1021/ac0703000
DO - 10.1021/ac0703000
M3 - Article
C2 - 17508721
AN - SCOPUS:34347271315
SN - 0003-2700
VL - 79
SP - 4702
EP - 4708
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 12
ER -