Abstract

As a whole, biological research has recently shifted its focus from reductionism to holistic approaches to study complex systems, a strategy often termed "systems biology". Nutritional research has progressed similarly, incorporating phenotype, genotype, genomics, and bioinformatics into an integrative molecular nutrition research model to study the impact of nutritional status on health and disease. Given the importance of livestock and companion animals as large animal models for humans, many of these genomes including that of the dog, cow, cat, and chicken have been sequenced or are being sequenced by the National Institutes of Health (NIH). Ongoing projects to sequence the canine genome and create a SNP map, in addition to the phenotypic and genotypic similarities and unique breed structure of domestic dogs, continue to increase the experimental power of the dog model. While anatomical and physiological similarities have deemed the dog a useful model for gastrointestinal research for decades, economical and ethical concerns have recently decreased their use in this research field. This review aims to reiterate the importance of the dog model in gastrointestinal research, including the study of prebiotics and aging on intestinal health, analyzing gene expression profiles to better understand intestinal diseases such as inflammatory bowel disease, and performing whole genome association studies to identify genetic loci contributing to complex intestinal diseases.

Original languageEnglish (US)
Pages (from-to)115-126
Number of pages12
JournalCurrent Nutrition and Food Science
Volume2
Issue number2
DOIs
StatePublished - May 1 2006

Fingerprint

Canidae
Diet
Dogs
dogs
Health
Research
diet
Intestinal Diseases
digestive system diseases
National Institutes of Health
Prebiotics
nutrition research
Genetic Loci
Systems Biology
genome
inflammatory bowel disease
Genome-Wide Association Study
Pets
National Institutes of Health (U.S.)
Livestock

Keywords

  • Canine
  • Functional genomics
  • Intestinal health
  • Nutrition
  • Systems biology

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health
  • Food Science

Cite this

Canine nutritional model : Influence of age, diet, and genetics on health and well-being. / Swanson, Kelly S; Schook, Lawrence B.

In: Current Nutrition and Food Science, Vol. 2, No. 2, 01.05.2006, p. 115-126.

Research output: Contribution to journalReview article

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