Canine distemper in a vaccinated snow leopard (Panthera uncia)

Sathya K. Chinnadurai, Michael J. Kinsel, Michael J. Adkesson, Karen Terio

Research output: Contribution to journalArticle

Abstract

A 6-yr-old male snow leopard (Panthera uncia) presented with acute seizures, hyperthermia, and tachypnea. Because of a diagnosis of anuric renal failure, the animal was euthanized. On histopathologic examination, numerous intralesional intracytoplasmic and intranuclear inclusions were found in the lungs, lymph nodes, and stomach. Positive immunohistochemical staining for canine distemper virus (CDV) was found in the lungs and, to a lesser extent, in the lymph nodes and brain. Molecular testing yielded a CDV H gene sequence that was closely related to CDV isolates concurrently found in wild raccoons from adjacent forested areas. The leopard had been vaccinated once against CDV with the use of a recombinant canarypox-vectored live vaccine during a routine wellness examination 12 wk prior to death. Serial serum neutralization titers performed on banked serum collected between vaccination and death showed poor serologic response to the vaccine. This case demonstrates a probable failure of protection against naturally occurring CDV.

Original languageEnglish (US)
Pages (from-to)1200-1203
Number of pages4
JournalJournal of Zoo and Wildlife Medicine
Volume48
Issue number4
DOIs
StatePublished - Dec 1 2017

Fingerprint

Distemper
Panthera uncia
Panthera
Canine Distemper Virus
canine distemper
Canine distemper virus
Felidae
lymph nodes
Vaccines
Lymph Nodes
lungs
Raccoons
death
Tachypnea
Intranuclear Inclusion Bodies
Lung
Procyon lotor
live vaccines
renal failure
seizures

Keywords

  • Canine distemper virus
  • Failure
  • Felid
  • Panthera uncia
  • Snow leopard
  • Vaccine

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Canine distemper in a vaccinated snow leopard (Panthera uncia). / Chinnadurai, Sathya K.; Kinsel, Michael J.; Adkesson, Michael J.; Terio, Karen.

In: Journal of Zoo and Wildlife Medicine, Vol. 48, No. 4, 01.12.2017, p. 1200-1203.

Research output: Contribution to journalArticle

Chinnadurai, Sathya K. ; Kinsel, Michael J. ; Adkesson, Michael J. ; Terio, Karen. / Canine distemper in a vaccinated snow leopard (Panthera uncia). In: Journal of Zoo and Wildlife Medicine. 2017 ; Vol. 48, No. 4. pp. 1200-1203.
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