Can sequence determine function?

John A. Gerlt, Patricia C. Babbitt

Research output: Contribution to journalArticlepeer-review


The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of function from sequence information alone should be viewed with some skepticism.

Original languageEnglish (US)
Pages (from-to)XIII-XIV
JournalGenome biology
Issue number5
StatePublished - 2000

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology


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