Cameo appearances of aminoacyl-tRNA in natural product biosynthesis

Research output: Contribution to journalReview article

Abstract

The breadth of unprecedented enzymatic reactions performed during the formation of microbial natural products has continued to expand as new biosynthetic gene clusters are unearthed by genome mining. Enzymes that use aminoacyl-tRNA (aa-tRNA) outside of the translation machinery have been known for decades, and accounts of their use in natural product biosynthesis are just beginning to accumulate. This review will highlight the recent discoveries and advances in our mechanistic understanding of aa-tRNA-dependent enzymes that play key roles in the biosynthesis of a growing number of microbial natural products.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalCurrent Opinion in Chemical Biology
Volume35
DOIs
StatePublished - Dec 1 2016

Fingerprint

Biosynthesis
Transfer RNA
Biological Products
Genes
Enzymes
Multigene Family
Machinery
Genome

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Cameo appearances of aminoacyl-tRNA in natural product biosynthesis. / Ulrich, Emily C.; van der Donk, Wilfred Adrianus.

In: Current Opinion in Chemical Biology, Vol. 35, 01.12.2016, p. 29-36.

Research output: Contribution to journalReview article

@article{4b2221621b684c3ca01b7b248cb46f1f,
title = "Cameo appearances of aminoacyl-tRNA in natural product biosynthesis",
abstract = "The breadth of unprecedented enzymatic reactions performed during the formation of microbial natural products has continued to expand as new biosynthetic gene clusters are unearthed by genome mining. Enzymes that use aminoacyl-tRNA (aa-tRNA) outside of the translation machinery have been known for decades, and accounts of their use in natural product biosynthesis are just beginning to accumulate. This review will highlight the recent discoveries and advances in our mechanistic understanding of aa-tRNA-dependent enzymes that play key roles in the biosynthesis of a growing number of microbial natural products.",
author = "Ulrich, {Emily C.} and {van der Donk}, {Wilfred Adrianus}",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.cbpa.2016.08.018",
language = "English (US)",
volume = "35",
pages = "29--36",
journal = "Current Opinion in Chemical Biology",
issn = "1367-5931",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Cameo appearances of aminoacyl-tRNA in natural product biosynthesis

AU - Ulrich, Emily C.

AU - van der Donk, Wilfred Adrianus

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The breadth of unprecedented enzymatic reactions performed during the formation of microbial natural products has continued to expand as new biosynthetic gene clusters are unearthed by genome mining. Enzymes that use aminoacyl-tRNA (aa-tRNA) outside of the translation machinery have been known for decades, and accounts of their use in natural product biosynthesis are just beginning to accumulate. This review will highlight the recent discoveries and advances in our mechanistic understanding of aa-tRNA-dependent enzymes that play key roles in the biosynthesis of a growing number of microbial natural products.

AB - The breadth of unprecedented enzymatic reactions performed during the formation of microbial natural products has continued to expand as new biosynthetic gene clusters are unearthed by genome mining. Enzymes that use aminoacyl-tRNA (aa-tRNA) outside of the translation machinery have been known for decades, and accounts of their use in natural product biosynthesis are just beginning to accumulate. This review will highlight the recent discoveries and advances in our mechanistic understanding of aa-tRNA-dependent enzymes that play key roles in the biosynthesis of a growing number of microbial natural products.

UR - http://www.scopus.com/inward/record.url?scp=84984986341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984986341&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2016.08.018

DO - 10.1016/j.cbpa.2016.08.018

M3 - Review article

C2 - 27599269

AN - SCOPUS:84984986341

VL - 35

SP - 29

EP - 36

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

SN - 1367-5931

ER -