TY - JOUR
T1 - Calling heads from tails
T2 - the role of mathematical modeling in understanding cell polarization
AU - Onsum, Matthew D.
AU - Rao, Christopher V.
N1 - Funding Information:
We thank members of the Merrimack Pharmaceuticals and the Rao lab for helpful comments. CVR is supported by the National Institutes of Health grant GM083601.
PY - 2009/2
Y1 - 2009/2
N2 - Theorists have long speculated on the mechanisms driving directed and spontaneous cell polarization. Recently, experimentalists have uncovered many of the mechanisms underlying polarization, enabling these models to be directly tested. In the process, they have demonstrated the explanatory and predictive value of these models and, at the same time, uncovered additional complexities not currently explained by them. In this review, we discuss some of main theories regarding cell polarization and highlight how the intersection of mathematical and experimental biology has yielded new insights into these mechanisms in the case of budding yeast and eukaryotic chemotaxis.
AB - Theorists have long speculated on the mechanisms driving directed and spontaneous cell polarization. Recently, experimentalists have uncovered many of the mechanisms underlying polarization, enabling these models to be directly tested. In the process, they have demonstrated the explanatory and predictive value of these models and, at the same time, uncovered additional complexities not currently explained by them. In this review, we discuss some of main theories regarding cell polarization and highlight how the intersection of mathematical and experimental biology has yielded new insights into these mechanisms in the case of budding yeast and eukaryotic chemotaxis.
UR - http://www.scopus.com/inward/record.url?scp=60749120831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60749120831&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2009.01.001
DO - 10.1016/j.ceb.2009.01.001
M3 - Review article
C2 - 19167872
AN - SCOPUS:60749120831
SN - 0955-0674
VL - 21
SP - 74
EP - 81
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -