Calling heads from tails: the role of mathematical modeling in understanding cell polarization

Matthew D. Onsum, Christopher V. Rao

Research output: Contribution to journalReview article

Abstract

Theorists have long speculated on the mechanisms driving directed and spontaneous cell polarization. Recently, experimentalists have uncovered many of the mechanisms underlying polarization, enabling these models to be directly tested. In the process, they have demonstrated the explanatory and predictive value of these models and, at the same time, uncovered additional complexities not currently explained by them. In this review, we discuss some of main theories regarding cell polarization and highlight how the intersection of mathematical and experimental biology has yielded new insights into these mechanisms in the case of budding yeast and eukaryotic chemotaxis.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Cell Biology

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