Calcium phosphate ceramics as substrate for cartilage cultivation

Rolf Janssen, Stephanie Nagel-Heyer, Christiane Goepfert, Ralf Pörtner, Derya Toykan, Oliver Krummhauer, Michael Morlock, Peter Adamietz, Norbert M. Meenen, Waltraud M. Kriven, Dong Kyu Kim, Anna Tampieri, Giancarlo Celotti

Research output: Contribution to journalConference articlepeer-review

Abstract

Hip, knee and shoulder joints are complex structures that bear a combination of articular cartilage, bone and synovial fluid. Articular cartilage is a shock-absorbing tough, connective tissue that covers the ends of bones in joints and enables the bones to glide over one another. Since there are no nerves or blood vessels in cartilage, once it is damaged it has a reduced ability to repair or restore itself. Thus, there has been continuous research on the regeneration of cartilage by tissue engineering. Our investigation is focussed on a tissue engineered cartilage-carrier-construct, where the cartilage is grown on top of a ceramic carrier as bone equivalent. Calcium phosphates are widely used as bioceramics due to their biocompatibility and bioactivity. Former in vivo (mini pig) investigations have demonstrated the potential of this concept for local cartilage repair. But still the properties of the carrier have to be optimised. In this study different types of calcium phosphate ceramics with different surface properties were investigated in order to generate cartilage on their surfaces. The results indicate that the adhesion of cartilage/calcium phosphate is a critical parameter for reliable implants.

Original languageEnglish (US)
Pages (from-to)523-528
Number of pages6
JournalCeramic Engineering and Science Proceedings
Volume25
Issue number4
StatePublished - 2004
Event28th International Conference on Advanced Ceramics and Composites - Cocoa Beach, FL, United States
Duration: Jan 25 2004Jan 30 2004

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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