CALCINOSIS CIRCUMSCRIPTA in A COHORT of RELATED JUVENILE AFRICAN LIONS (PANTHERA LEO)

Kendra L. Bauer, Samantha J. Sander, James C. Steeil, Timothy F. Walsh, Donald L. Neiffer

Research output: Contribution to journalArticle

Abstract

Three juvenile, genetically related African lions (Panthera leo) were evaluated for discrete dome-shaped subcutaneous masses present over the proximal lateral metatarsal-tarsal area. The lesions measured 3-8 cm in diameter, were fluctuant to firm, nonulcerated, and attached to underlying structures. On radiographic evaluation, the lesions were characterized by well-circumscribed punctate mineralizations in the soft tissue surrounded by soft tissue swelling without evidence of adjacent bony involvement. On cut surface, the lesions were made of numerous loculi containing 2-5-mm round-to-ovoid, white-to-gray, firm structures interspersed with fibrous tissue and pockets of serosanguinous fluid. Hematology, serum biochemistry, serum thyroid screening (including total thyroxine, total triiodothyronine, free thyroxine, and free triiodothyronine), and serum vitamin D panels (including parathyroid hormone, ionized calcium, and 25-hydroxyvitamin D) were unremarkable. Histopathologic evaluation of the lesions was consistent with calcinosis circumscripta with fibroplasia, chronic inflammation, and seroma formation. An additional two genetically related lions were considered suspect for calcinosis circumscripta based on presentation, exam findings, and similarity to the confirmed cases. All masses self-regressed and were not associated with additional clinical signs other than initial lameness in two cases.

Original languageEnglish (US)
Pages (from-to)813-817
Number of pages5
JournalJournal of Zoo and Wildlife Medicine
Volume48
Issue number3
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Fingerprint

Lions
Panthera leo
lesions (animal)
Calcinosis
Triiodothyronine
calcinosis
Thyroxine
triiodothyronine
thyroxine
Serum
Seroma
Metatarsal Bones
Hematology
Parathyroid Hormone
Vitamin D
Biochemistry
parathyroid hormone
Thyroid Gland
hematology
vitamin D

Keywords

  • Calcinosis circumscripta
  • Lion
  • Panthera leo
  • Skin
  • Tumoral calcinosis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

CALCINOSIS CIRCUMSCRIPTA in A COHORT of RELATED JUVENILE AFRICAN LIONS (PANTHERA LEO). / Bauer, Kendra L.; Sander, Samantha J.; Steeil, James C.; Walsh, Timothy F.; Neiffer, Donald L.

In: Journal of Zoo and Wildlife Medicine, Vol. 48, No. 3, 01.09.2017, p. 813-817.

Research output: Contribution to journalArticle

Bauer, Kendra L. ; Sander, Samantha J. ; Steeil, James C. ; Walsh, Timothy F. ; Neiffer, Donald L. / CALCINOSIS CIRCUMSCRIPTA in A COHORT of RELATED JUVENILE AFRICAN LIONS (PANTHERA LEO). In: Journal of Zoo and Wildlife Medicine. 2017 ; Vol. 48, No. 3. pp. 813-817.
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