Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation

Fatima J. Zapata, Miguel Rebollo-Hernanz, Jan E. Novakofski, Manabu T. Nakamura, Elvira Gonzalez de Mejia

Research output: Contribution to journalArticle

Abstract

The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity. MC and decaffeinated mate (DM) were obtained using supercritical CO2 extraction and mainly composed of caffeine and caffeoylquinic acids, respectively. MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid. Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression.

Original languageEnglish (US)
Article number103646
JournalJournal of Functional Foods
Volume64
DOIs
StatePublished - Jan 2020

Fingerprint

Ilex paraguariensis
Lipogenesis
lipogenesis
Phytochemicals
High Fat Diet
Tea
caffeine
Caffeine
tea
phytopharmaceuticals
body fat
Sucrose
Adipose Tissue
sucrose
Fatty Acid Synthases
fatty-acid synthase
lipids
diet
Weight Gain
acids

Keywords

  • Caffeine
  • Fat accumulation
  • Ilex paraguariensis
  • Lipogenesis
  • Obesity
  • Yerba mate

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

@article{b850f9d8dc2d49d89d9d088b4ad86359,
title = "Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation",
abstract = "The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity. MC and decaffeinated mate (DM) were obtained using supercritical CO2 extraction and mainly composed of caffeine and caffeoylquinic acids, respectively. MC reduced lipid accumulation (41{\%}) via downregulation of fatty acid synthase (Fasn) (39{\%}) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1{\%} of caffeine from MC, MT, or DM. MC attenuated weight gain (16{\%}) and body fat accumulation (22{\%}). MC reduced Fasn expression in both adipose tissue (66{\%}) and liver (37{\%}). MC diminished pyruvate kinase (PK, 59{\%}) and microsomal triglyceride transfer protein (MTP, 50{\%}) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid. Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression.",
keywords = "Caffeine, Fat accumulation, Ilex paraguariensis, Lipogenesis, Obesity, Yerba mate",
author = "Zapata, {Fatima J.} and Miguel Rebollo-Hernanz and Novakofski, {Jan E.} and Nakamura, {Manabu T.} and {Gonzalez de Mejia}, Elvira",
year = "2020",
month = "1",
doi = "10.1016/j.jff.2019.103646",
language = "English (US)",
volume = "64",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Limited",

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TY - JOUR

T1 - Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven lipogenesis and body fat accumulation

AU - Zapata, Fatima J.

AU - Rebollo-Hernanz, Miguel

AU - Novakofski, Jan E.

AU - Nakamura, Manabu T.

AU - Gonzalez de Mejia, Elvira

PY - 2020/1

Y1 - 2020/1

N2 - The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity. MC and decaffeinated mate (DM) were obtained using supercritical CO2 extraction and mainly composed of caffeine and caffeoylquinic acids, respectively. MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid. Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression.

AB - The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity. MC and decaffeinated mate (DM) were obtained using supercritical CO2 extraction and mainly composed of caffeine and caffeoylquinic acids, respectively. MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid. Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression.

KW - Caffeine

KW - Fat accumulation

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KW - Lipogenesis

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