Cadherin-dependent cell morphology in an epithelium

Constructing a quantitative dynamical model

Ian M. Gemp, Richard W. Carthew, Sascha Hilgenfeldt

Research output: Contribution to journalArticle

Abstract

Cells in the Drosophila retina have well-defined morphologies that are attained during tissue morphogenesis. We present a computer simulation of the epithelial tissue in which the global interfacial energy between cells is minimized. Experimental data for both normal cells and mutant cells either lacking or misexpressing the adhesion protein N-cadherin can be explained by a simple model incorporating salient features of morphogenesis that include the timing of N-cadherin expression in cells and its temporal relationship to the remodeling of cell-cell contacts. The simulations reproduce the geometries of wild-type and mutant cells, distinguish features of cadherin dynamics, and emphasize the importance of adhesion protein biogenesis and its timing with respect to cell remodeling. The simulations also indicate that N-cadherin protein is recycled from inactive interfaces to active interfaces, thereby modulating adhesion strengths between cells.

Original languageEnglish (US)
Article numbere1002115
JournalPLoS Computational Biology
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2011

Fingerprint

cadherins
Dynamical Model
Cadherins
adhesion
epithelium
Epithelium
morphogenesis
Proteins
protein
Dependent
Cell
Adhesion
Tissue
Bond strength (materials)
cells
Interfacial energy
computer simulation
simulation
Remodeling
Morphogenesis

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Ecology
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics

Cite this

Cadherin-dependent cell morphology in an epithelium : Constructing a quantitative dynamical model. / Gemp, Ian M.; Carthew, Richard W.; Hilgenfeldt, Sascha.

In: PLoS Computational Biology, Vol. 7, No. 7, e1002115, 01.07.2011.

Research output: Contribution to journalArticle

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