C-H bond functionalization & synthesis in the 21st century: A brief history and prospectus

Research output: Contribution to journalReview article

Abstract

Among the frontier challenges facing synthetic chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity and synthesizing complex molecules with higher levels of efficiency. Catalytic C-H bond functionalization reactions are increasingly being discovered that meet the criterion for useful reactivity (i.e. preparative, predictably selective, and general). Consequently, such reactions are enabling chemists to exploit strategies for complex molecule synthesis and derivatization previously accessible only in nature. This preface highlights some of the achievements and important challenges that remain in the area of C-H bond functionalization.

Original languageEnglish (US)
Pages (from-to)2746-2748
Number of pages3
JournalSynlett
Volume23
Issue number19
DOIs
StatePublished - Nov 26 2012

Fingerprint

Chemical reactivity
Molecules

Keywords

  • C-H activation
  • bio-inspired methods
  • complex molecule synthesis
  • site-selective oxidation
  • synthetic efficiency

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

C-H bond functionalization & synthesis in the 21st century : A brief history and prospectus. / White, M. Christina.

In: Synlett, Vol. 23, No. 19, 26.11.2012, p. 2746-2748.

Research output: Contribution to journalReview article

@article{f962eaf1eb934fae8a22306779217288,
title = "C-H bond functionalization & synthesis in the 21st century: A brief history and prospectus",
abstract = "Among the frontier challenges facing synthetic chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity and synthesizing complex molecules with higher levels of efficiency. Catalytic C-H bond functionalization reactions are increasingly being discovered that meet the criterion for useful reactivity (i.e. preparative, predictably selective, and general). Consequently, such reactions are enabling chemists to exploit strategies for complex molecule synthesis and derivatization previously accessible only in nature. This preface highlights some of the achievements and important challenges that remain in the area of C-H bond functionalization.",
keywords = "C-H activation, bio-inspired methods, complex molecule synthesis, site-selective oxidation, synthetic efficiency",
author = "White, {M. Christina}",
year = "2012",
month = "11",
day = "26",
doi = "10.1055/s-0032-1317701",
language = "English (US)",
volume = "23",
pages = "2746--2748",
journal = "Synlett",
issn = "0936-5214",
publisher = "Georg Thieme Verlag",
number = "19",

}

TY - JOUR

T1 - C-H bond functionalization & synthesis in the 21st century

T2 - A brief history and prospectus

AU - White, M. Christina

PY - 2012/11/26

Y1 - 2012/11/26

N2 - Among the frontier challenges facing synthetic chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity and synthesizing complex molecules with higher levels of efficiency. Catalytic C-H bond functionalization reactions are increasingly being discovered that meet the criterion for useful reactivity (i.e. preparative, predictably selective, and general). Consequently, such reactions are enabling chemists to exploit strategies for complex molecule synthesis and derivatization previously accessible only in nature. This preface highlights some of the achievements and important challenges that remain in the area of C-H bond functionalization.

AB - Among the frontier challenges facing synthetic chemistry in the 21st century are the interconnected goals of increasing control of chemical reactivity and synthesizing complex molecules with higher levels of efficiency. Catalytic C-H bond functionalization reactions are increasingly being discovered that meet the criterion for useful reactivity (i.e. preparative, predictably selective, and general). Consequently, such reactions are enabling chemists to exploit strategies for complex molecule synthesis and derivatization previously accessible only in nature. This preface highlights some of the achievements and important challenges that remain in the area of C-H bond functionalization.

KW - C-H activation

KW - bio-inspired methods

KW - complex molecule synthesis

KW - site-selective oxidation

KW - synthetic efficiency

UR - http://www.scopus.com/inward/record.url?scp=84869415114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869415114&partnerID=8YFLogxK

U2 - 10.1055/s-0032-1317701

DO - 10.1055/s-0032-1317701

M3 - Review article

AN - SCOPUS:84869415114

VL - 23

SP - 2746

EP - 2748

JO - Synlett

JF - Synlett

SN - 0936-5214

IS - 19

ER -