Abstract
We examined the time-course of expression of c-fos and jun-B mRNAs in the fetal rat suprachiasmatic nuclei (SCN) following maternal cocaine injection on gestational day 20. Both c-fos and jun-B mRNA levels increased within 20 min, peaked at 40 min and declined to baseline by 120 min after cocaine treatment (30 mg/kg). In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock.
Original language | English (US) |
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Pages (from-to) | 293-297 |
Number of pages | 5 |
Journal | Developmental Brain Research |
Volume | 85 |
Issue number | 2 |
DOIs | |
State | Published - Apr 18 1995 |
Externally published | Yes |
Keywords
- Circadian rhythm
- Cocaine
- SKF 38393
- Suprachiasmatic nucleus
- c-fos
- fetus
- jun-B
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology