C-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation

David R. Weaver; Alfred L. Roca; Steven M. Reppert

doi:10.1016/0165-3806(95)00016-7

C-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation

David R. Weaver, Alfred L. Roca, Steven M. Reppert

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the time-course of expression of c-fos and jun-B mRNAs in the fetal rat suprachiasmatic nuclei (SCN) following maternal cocaine injection on gestational day 20. Both c-fos and jun-B mRNA levels increased within 20 min, peaked at 40 min and declined to baseline by 120 min after cocaine treatment (30 mg/kg). In mice, the D₁-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock.

Original language	English (US)
Pages (from-to)	293-297
Number of pages	5
Journal	Developmental Brain Research
Volume	85
Issue number	2
DOIs	https://doi.org/10.1016/0165-3806(95)00016-7
State	Published - Apr 18 1995
Externally published	Yes

Keywords

Circadian rhythm
Cocaine
SKF 38393
Suprachiasmatic nucleus
c-fos
fetus
jun-B

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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title = "C-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation",

abstract = "We examined the time-course of expression of c-fos and jun-B mRNAs in the fetal rat suprachiasmatic nuclei (SCN) following maternal cocaine injection on gestational day 20. Both c-fos and jun-B mRNA levels increased within 20 min, peaked at 40 min and declined to baseline by 120 min after cocaine treatment (30 mg/kg). In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock.",

keywords = "Circadian rhythm, Cocaine, SKF 38393, Suprachiasmatic nucleus, c-fos, fetus, jun-B",

author = "Weaver, {David R.} and Roca, {Alfred L.} and Reppert, {Steven M.}",

note = "Funding Information: We thank Deborah Sodickson for technical assistance in Experiment 2 and Paul Batista for assistance in preparation of Fig. 2. This work was supported by NIH Grant HD14427 to S.M. Reppert. ALR was supported in part by a National Science Foundation Predoctoral Fellowship. Portions of this work were presented at the Fourth meeting of the Society for Research on Biological Rhythms, Jacksonville FL, May, 1994.",

year = "1995",

month = apr,

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doi = "10.1016/0165-3806(95)00016-7",

language = "English (US)",

volume = "85",

pages = "293--297",

journal = "Developmental Brain Research",

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TY - JOUR

T1 - C-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation

AU - Weaver, David R.

AU - Roca, Alfred L.

AU - Reppert, Steven M.

N1 - Funding Information: We thank Deborah Sodickson for technical assistance in Experiment 2 and Paul Batista for assistance in preparation of Fig. 2. This work was supported by NIH Grant HD14427 to S.M. Reppert. ALR was supported in part by a National Science Foundation Predoctoral Fellowship. Portions of this work were presented at the Fourth meeting of the Society for Research on Biological Rhythms, Jacksonville FL, May, 1994.

PY - 1995/4/18

Y1 - 1995/4/18

N2 - We examined the time-course of expression of c-fos and jun-B mRNAs in the fetal rat suprachiasmatic nuclei (SCN) following maternal cocaine injection on gestational day 20. Both c-fos and jun-B mRNA levels increased within 20 min, peaked at 40 min and declined to baseline by 120 min after cocaine treatment (30 mg/kg). In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock.

AB - We examined the time-course of expression of c-fos and jun-B mRNAs in the fetal rat suprachiasmatic nuclei (SCN) following maternal cocaine injection on gestational day 20. Both c-fos and jun-B mRNA levels increased within 20 min, peaked at 40 min and declined to baseline by 120 min after cocaine treatment (30 mg/kg). In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock.

KW - Circadian rhythm

KW - Cocaine

KW - SKF 38393

KW - Suprachiasmatic nucleus

KW - c-fos

KW - fetus

KW - jun-B

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VL - 85

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EP - 297

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 2

ER -

C-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation

Abstract

Keywords

ASJC Scopus subject areas

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