C-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation

David R. Weaver, Alfred L. Roca, Steven M. Reppert

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the time-course of expression of c-fos and jun-B mRNAs in the fetal rat suprachiasmatic nuclei (SCN) following maternal cocaine injection on gestational day 20. Both c-fos and jun-B mRNA levels increased within 20 min, peaked at 40 min and declined to baseline by 120 min after cocaine treatment (30 mg/kg). In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalDevelopmental Brain Research
Volume85
Issue number2
DOIs
StatePublished - Apr 18 1995
Externally publishedYes

Keywords

  • Circadian rhythm
  • Cocaine
  • SKF 38393
  • Suprachiasmatic nucleus
  • c-fos
  • fetus
  • jun-B

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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