TY - JOUR
T1 - BV-BRC
T2 - a unified bacterial and viral bioinformatics resource with expanded functionality and AI integration
AU - Shukla, Maulik
AU - Wattam, Alice R.
AU - Aleman, Antonio
AU - Bhattacharya, Roshni
AU - Bowers, Nicole
AU - Brettin, Thomas
AU - Capria, Anna
AU - Chia, Nicholas
AU - Cucinell, Clark
AU - Davis, James J.
AU - Dempsey, Donald M.
AU - Dickerman, Allan
AU - Dietrich, Emily M.
AU - Gokdemir, Ozan
AU - Hendrickson, R. Curtis
AU - Kenyon, Ronald W.
AU - Klahn, Brian
AU - Kuscuoglu, Mehmet
AU - Lefkowitz, Elliot J.
AU - Ma, Heng
AU - Machi, Dustin
AU - Macken, Catherine
AU - Mann, Carla M.
AU - Mao, Chunhong
AU - Nguyen, Marcus
AU - Olsen, Gary J.
AU - Olson, Robert D.
AU - Overbeek, Ross
AU - Owens, Sarah M.
AU - Parrello, Bruce
AU - Poretsky, Rachel
AU - Pusch, Gordon D.
AU - Ramanathan, Arvind
AU - Sheriff, Jamal Tyrone
AU - Singh, Indresh
AU - Stewart, Lucy
AU - VanOeffelen, Margo
AU - Vonstein, Veronika
AU - Warren, Andrew S.
AU - Wilke, Andreas
AU - Zmasek, Christian M.
AU - Zuniga, Abril
AU - Stevens, Rick L.
N1 - Publisher Copyright:
© Published by Oxford University Press 2025.
PY - 2026/1/6
Y1 - 2026/1/6
N2 - The Bacterial and Viral Bioinformatics Resource Center (BV-BRC; https://www.bv-brc.org) is a comprehensive resource supporting research on bacterial and viral pathogens. It currently hosts over 14 million publicly available genomes and 33 high-throughput bioinformatic analysis services with numerous visual analytic tools allowing researchers to analyze their private data, generate comparisons with public data, and share data and results with colleagues. In recent years, the BV-BRC has added several new analysis services to support rapid comparative genomics and epidemiological analysis, viral genome assembly and annotation, viral subspecies classification, wastewater analysis, and molecular docking. In addition, several existing services have been updated to incorporate state-of-the-art tools, including assembly, annotation, taxonomic classification, metagenomic read mapping, and RNA-seq analysis. A new tool, called BV-BRC Copilot, provides an AI-powered natural-language interface that combines large language models with retrieval-augmented generation to guide users through data exploration, analysis workflows, and knowledge integration. With expanded outbreak tracking pages, training and educator engagement, and continued development of novel AI-driven analytics, BV-BRC continues to provide a unified resource to meet the evolving needs of the global research community.
AB - The Bacterial and Viral Bioinformatics Resource Center (BV-BRC; https://www.bv-brc.org) is a comprehensive resource supporting research on bacterial and viral pathogens. It currently hosts over 14 million publicly available genomes and 33 high-throughput bioinformatic analysis services with numerous visual analytic tools allowing researchers to analyze their private data, generate comparisons with public data, and share data and results with colleagues. In recent years, the BV-BRC has added several new analysis services to support rapid comparative genomics and epidemiological analysis, viral genome assembly and annotation, viral subspecies classification, wastewater analysis, and molecular docking. In addition, several existing services have been updated to incorporate state-of-the-art tools, including assembly, annotation, taxonomic classification, metagenomic read mapping, and RNA-seq analysis. A new tool, called BV-BRC Copilot, provides an AI-powered natural-language interface that combines large language models with retrieval-augmented generation to guide users through data exploration, analysis workflows, and knowledge integration. With expanded outbreak tracking pages, training and educator engagement, and continued development of novel AI-driven analytics, BV-BRC continues to provide a unified resource to meet the evolving needs of the global research community.
UR - https://www.scopus.com/pages/publications/105027810312
UR - https://www.scopus.com/pages/publications/105027810312#tab=citedBy
U2 - 10.1093/nar/gkaf1254
DO - 10.1093/nar/gkaf1254
M3 - Article
C2 - 41251138
AN - SCOPUS:105027810312
SN - 0305-1048
VL - 54
SP - D715-D723
JO - Nucleic acids research
JF - Nucleic acids research
IS - 1
ER -