Building biological foundries for next-generation synthetic biology

Ran Chao, Yong Bo Yuan, Hui Min Zhao

Research output: Contribution to journalReview articlepeer-review


Synthetic biology is an interdisciplinary field that takes top-down approaches to understand and engineer biological systems through design-build-test cycles. A number of advances in this relatively young field have greatly accelerated such engineering cycles. Specifically, various innovative tools were developed for in silico biosystems design, DNA de novo synthesis and assembly, construct verification, as well as metabolite analysis, which have laid a solid foundation for building biological foundries for rapid prototyping of improved or novel biosystems. This review summarizes the state-of-the-art technologies for synthetic biology and discusses the challenges to establish such biological foundries.

Original languageEnglish (US)
Pages (from-to)658-665
Number of pages8
JournalScience China Life Sciences
Issue number7
StatePublished - Jul 24 2015


  • DNA assembly
  • DNA sequencing
  • automation
  • biofabrication
  • biosystems design
  • metabolic engineering
  • metabolite analysis

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Environmental Science
  • General Agricultural and Biological Sciences


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