Bromodomain and extraterminal proteins - A novel class of therapeutic targets in epigenetics

Jin Jing Chen, Xiao Li Zhao, Zhen Wang, Lin Feng Chen

Research output: Contribution to journalReview article

Abstract

Bromodomain and extraterminal (BET) proteins are a class of proteins that can interpret epigenetic codes and play an important role in regulating gene transcription through identifying and binding acetylated histones or non-histones proteins. The BET inhibitors have emerged with good therapeutic effects in preclinical disease models such as cancer and inflammation. Some of them have entered clinical studies, demonstrating that there is considerable prospect for drug development with BET as a potential therapeutic target. This review briefly describes the structures and functions of the BET proteins, the BET inhibitors in various diseases, as well as molecular mechanisms involved.

Original languageEnglish (US)
Pages (from-to)1209-1215
Number of pages7
JournalYaoxue Xuebao
Volume52
Issue number8
DOIs
StatePublished - Jan 1 2017

Keywords

  • Bromodomain and extraterminal
  • Bromodomain containing 4
  • Chromatin regulation
  • Epigenetics
  • Therapeutic target

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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