We present a method to utilize 'guide stars' within a sample, as in hardware-based adaptive optics, in order to correct aberrations using computational adaptive optics. Interferometric synthetic aperture microscopy (ISAM), a computed imaging technique to overcome the depth-of-field limitations in optical coherence tomography/microscopy (OCT/OCM), is utilized to correct defocus and reveal local high-scattering regions that can serve as potential guide stars. The correction of pupil aberrations using Zernike polynomials can be applied pre- or post-ISAM in order to improve resolution and signal-to-noise ratio of these guide stars. Aberrations of the effective pupil function can then be determined through subsequent windowing and Fourier transforming of a guide star signal. Computational adaptive optics based on guide stars is demonstrated in a phantom consisting of sub-resolution scatterers, with work underway to extend this method to biological tissues.

Original languageEnglish (US)
Title of host publicationFrontiers in Optics, FIO 2012
PublisherOptical Society of America (OSA)
ISBN (Print)9781557529565
StatePublished - 2012
EventFrontiers in Optics, FIO 2012 - Rochester, NY, United States
Duration: Oct 14 2012Oct 18 2012

Publication series

NameFrontiers in Optics, FIO 2012


OtherFrontiers in Optics, FIO 2012
Country/TerritoryUnited States
CityRochester, NY

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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