We present a method to utilize 'guide stars' within a sample, as in hardware-based adaptive optics, in order to correct aberrations using computational adaptive optics. Interferometric synthetic aperture microscopy (ISAM), a computed imaging technique to overcome the depth-of-field limitations in optical coherence tomography/microscopy (OCT/OCM), is utilized to correct defocus and reveal local high-scattering regions that can serve as potential guide stars. The correction of pupil aberrations using Zernike polynomials can be applied pre- or post-ISAM in order to improve resolution and signal-to-noise ratio of these guide stars. Aberrations of the effective pupil function can then be determined through subsequent windowing and Fourier transforming of a guide star signal. Computational adaptive optics based on guide stars is demonstrated in a phantom consisting of sub-resolution scatterers, with work underway to extend this method to biological tissues.

Original languageEnglish (US)
Title of host publicationFrontiers in Optics, FIO 2012
StatePublished - Dec 1 2012
EventFrontiers in Optics, FIO 2012 - Rochester, NY, United States
Duration: Oct 14 2012Oct 18 2012

Publication series

NameFrontiers in Optics, FIO 2012


OtherFrontiers in Optics, FIO 2012
CountryUnited States
CityRochester, NY

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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