Breastfeeding and prolactin levels in lactating women with a family history of alcoholism

Julie A. Mennella, Marta Yanina Pepino

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Many motivated new mothers fail to reach public health goals for breastfeeding, highlighting the need to identify risk factors. Because having a family history of alcoholism is associated with blunted prolactin responses to an alcohol challenge in nonlactating individuals, this study aimed to identify associations in family history of alcoholism, prolactin, and breastfeeding behaviors in lactating women. METHODS: This was a 2-day experimental study that used within-subject alcohol or control beverage consumption and between-subject family history of alcoholism factors. The participants were non-alcohol- dependent lactating women; 7 were family history-positive (FHP) for alcohol dependence, and 21 were family history-negative (FHN). Consumption of 0.4 g/kg alcohol or nonalcoholic beverage occurred in separate randomized sessions, followed by use of a breast pump. Basal and suckling-induced prolactin, blood alcohol concentrations, milk yield, self-reported drug effects, neophobia, and breastfeeding patterning were measured. RESULTS: Although no group differences in alcohol pharmacokinetics were detected, FHP women exhibited blunted prolactin to breast stimulation after drinking the control and alcohol beverage and felt more of the stimulant-like effects of alcohol than did FHN women. FHP women reported more frequent daily breastfeeding than did FHN women. CONCLUSIONS: This is the first evidence that family history of alcoholism is associated with a blunted magnitude, rapidity, and duration of the prolactin response to breast stimulation and an alcohol challenge in lactating women. More frequent breastfeeding by FHP women suggests behavioral compensation for perceived and/or actual poor lactation. Alcohol did not enhance lactational performance, further disputing the lore that alcohol is a galactagogue.

Original languageEnglish (US)
Pages (from-to)e1162-e1170
JournalPediatrics
Volume125
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Breast Feeding
Prolactin
Alcoholism
Alcohols
Beverages
Breast
Lactation
Alcohol Drinking
Milk
Pharmacokinetics
Public Health
Mothers

Keywords

  • Alcohol
  • Breastfeeding
  • Drug effects
  • Endocrinology
  • Lactation
  • Prolactin
  • Risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Breastfeeding and prolactin levels in lactating women with a family history of alcoholism. / Mennella, Julie A.; Pepino, Marta Yanina.

In: Pediatrics, Vol. 125, No. 5, 01.05.2010, p. e1162-e1170.

Research output: Contribution to journalArticle

@article{3e624a59cd4b48d9bef3631acb2850cc,
title = "Breastfeeding and prolactin levels in lactating women with a family history of alcoholism",
abstract = "OBJECTIVE: Many motivated new mothers fail to reach public health goals for breastfeeding, highlighting the need to identify risk factors. Because having a family history of alcoholism is associated with blunted prolactin responses to an alcohol challenge in nonlactating individuals, this study aimed to identify associations in family history of alcoholism, prolactin, and breastfeeding behaviors in lactating women. METHODS: This was a 2-day experimental study that used within-subject alcohol or control beverage consumption and between-subject family history of alcoholism factors. The participants were non-alcohol- dependent lactating women; 7 were family history-positive (FHP) for alcohol dependence, and 21 were family history-negative (FHN). Consumption of 0.4 g/kg alcohol or nonalcoholic beverage occurred in separate randomized sessions, followed by use of a breast pump. Basal and suckling-induced prolactin, blood alcohol concentrations, milk yield, self-reported drug effects, neophobia, and breastfeeding patterning were measured. RESULTS: Although no group differences in alcohol pharmacokinetics were detected, FHP women exhibited blunted prolactin to breast stimulation after drinking the control and alcohol beverage and felt more of the stimulant-like effects of alcohol than did FHN women. FHP women reported more frequent daily breastfeeding than did FHN women. CONCLUSIONS: This is the first evidence that family history of alcoholism is associated with a blunted magnitude, rapidity, and duration of the prolactin response to breast stimulation and an alcohol challenge in lactating women. More frequent breastfeeding by FHP women suggests behavioral compensation for perceived and/or actual poor lactation. Alcohol did not enhance lactational performance, further disputing the lore that alcohol is a galactagogue.",
keywords = "Alcohol, Breastfeeding, Drug effects, Endocrinology, Lactation, Prolactin, Risk factors",
author = "Mennella, {Julie A.} and Pepino, {Marta Yanina}",
year = "2010",
month = "5",
day = "1",
doi = "10.1542/peds.2009-3040",
language = "English (US)",
volume = "125",
pages = "e1162--e1170",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "5",

}

TY - JOUR

T1 - Breastfeeding and prolactin levels in lactating women with a family history of alcoholism

AU - Mennella, Julie A.

AU - Pepino, Marta Yanina

PY - 2010/5/1

Y1 - 2010/5/1

N2 - OBJECTIVE: Many motivated new mothers fail to reach public health goals for breastfeeding, highlighting the need to identify risk factors. Because having a family history of alcoholism is associated with blunted prolactin responses to an alcohol challenge in nonlactating individuals, this study aimed to identify associations in family history of alcoholism, prolactin, and breastfeeding behaviors in lactating women. METHODS: This was a 2-day experimental study that used within-subject alcohol or control beverage consumption and between-subject family history of alcoholism factors. The participants were non-alcohol- dependent lactating women; 7 were family history-positive (FHP) for alcohol dependence, and 21 were family history-negative (FHN). Consumption of 0.4 g/kg alcohol or nonalcoholic beverage occurred in separate randomized sessions, followed by use of a breast pump. Basal and suckling-induced prolactin, blood alcohol concentrations, milk yield, self-reported drug effects, neophobia, and breastfeeding patterning were measured. RESULTS: Although no group differences in alcohol pharmacokinetics were detected, FHP women exhibited blunted prolactin to breast stimulation after drinking the control and alcohol beverage and felt more of the stimulant-like effects of alcohol than did FHN women. FHP women reported more frequent daily breastfeeding than did FHN women. CONCLUSIONS: This is the first evidence that family history of alcoholism is associated with a blunted magnitude, rapidity, and duration of the prolactin response to breast stimulation and an alcohol challenge in lactating women. More frequent breastfeeding by FHP women suggests behavioral compensation for perceived and/or actual poor lactation. Alcohol did not enhance lactational performance, further disputing the lore that alcohol is a galactagogue.

AB - OBJECTIVE: Many motivated new mothers fail to reach public health goals for breastfeeding, highlighting the need to identify risk factors. Because having a family history of alcoholism is associated with blunted prolactin responses to an alcohol challenge in nonlactating individuals, this study aimed to identify associations in family history of alcoholism, prolactin, and breastfeeding behaviors in lactating women. METHODS: This was a 2-day experimental study that used within-subject alcohol or control beverage consumption and between-subject family history of alcoholism factors. The participants were non-alcohol- dependent lactating women; 7 were family history-positive (FHP) for alcohol dependence, and 21 were family history-negative (FHN). Consumption of 0.4 g/kg alcohol or nonalcoholic beverage occurred in separate randomized sessions, followed by use of a breast pump. Basal and suckling-induced prolactin, blood alcohol concentrations, milk yield, self-reported drug effects, neophobia, and breastfeeding patterning were measured. RESULTS: Although no group differences in alcohol pharmacokinetics were detected, FHP women exhibited blunted prolactin to breast stimulation after drinking the control and alcohol beverage and felt more of the stimulant-like effects of alcohol than did FHN women. FHP women reported more frequent daily breastfeeding than did FHN women. CONCLUSIONS: This is the first evidence that family history of alcoholism is associated with a blunted magnitude, rapidity, and duration of the prolactin response to breast stimulation and an alcohol challenge in lactating women. More frequent breastfeeding by FHP women suggests behavioral compensation for perceived and/or actual poor lactation. Alcohol did not enhance lactational performance, further disputing the lore that alcohol is a galactagogue.

KW - Alcohol

KW - Breastfeeding

KW - Drug effects

KW - Endocrinology

KW - Lactation

KW - Prolactin

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=77951845512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951845512&partnerID=8YFLogxK

U2 - 10.1542/peds.2009-3040

DO - 10.1542/peds.2009-3040

M3 - Article

C2 - 20403941

AN - SCOPUS:77951845512

VL - 125

SP - e1162-e1170

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 5

ER -