Breast ultrasound computed tomography using waveform inversion with source encoding

Kun Wang, Thomas Matthews, Fatima Anis, Cuiping Li, Neb Duric, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Ultrasound computed tomography (USCT) holds great promise for improving the detection and management of breast cancer. Because they are based on the acoustic wave equation, waveform inversion-based reconstruction methods can produce images that possess improved spatial resolution properties over those produced by ray-based methods. However, waveform inversion methods are computationally demanding and have not been applied widely in USCT breast imaging. In this work, source encoding concepts are employed to develop an accelerated USCT reconstruction method that circumvents the large computational burden of conventional waveform inversion methods. This method, referred to as the waveform inversion with source encoding (WISE) method, encodes the measurement data using a random encoding vector and determines an estimate of the speed-of-sound distribution by solving a stochastic optimization problem by use of a stochastic gradient descent algorithm. Computer-simulation studies are conducted to demonstrate the use of the WISE method. Using a single graphics processing unit card, each iteration can be completed within 25 seconds for a 128 × 128 mm 2 reconstruction region. The results suggest that the WISE method maintains the high spatial resolution of waveform inversion methods while significantly reducing the computational burden.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationUltrasonic Imaging and Tomography
EditorsNeb Duric, Johan G. Bosch
ISBN (Electronic)9781628415094
StatePublished - Jan 1 2015
Externally publishedYes
EventMedical Imaging 2015: Ultrasonic Imaging and Tomography - Orlando, United States
Duration: Feb 22 2015Feb 23 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2015: Ultrasonic Imaging and Tomography
CountryUnited States

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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