TY - JOUR
T1 - Breast cancer among women in Michigan following exposure to brominated flame retardants
AU - Terrell, Metrecia L.
AU - Rosenblatt, Karin A.
AU - Wirth, Julie
AU - Cameron, Lorraine L.
AU - Marcus, Michele
N1 - Funding Information:
The National Institutes of Health (R03 CA123623, R01 ES08341, R01 ES012014), the US Environmental Protection Agency (R 825300), and the Centers for Disease Control and Prevention (U37/CCU500392).
Publisher Copyright:
© Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/8
Y1 - 2016/8
N2 - In this updated follow-up, we investigated the breast cancer experience among women in Michigan exposed to brominated flame retardants, some 30years following exposure. Michigan residents were enrolled in a study cohort after exposure to polybrominated biphenyls (PBBs) through the consumption of contaminated food products. PBB concentrations were measured in serum at the time of enrolment. Cancer experience was determined by linkage to the Michigan Cancer Registry. We conducted a nested case-control study that included 51 women diagnosed with breast cancer during 1974-2004 and 202 age-matched controls. While the data suggest an increase in breast cancer risk with higher PBB exposure, this did not reach statistical significance. The OR of having breast cancer among women with PBB concentrations ≥10ng/mL compared to women with PBB concentrations at or below the limit of detection of 1ng/mL was 2.60, 95% CI 0.93 to 7.27, (p=0.07), when adjusted for age and family history of cancer in a first-degree female relative. It remains important to examine exposure to brominated chemicals and possible health effects, and to continue following the cancer experience of participants in this study.
AB - In this updated follow-up, we investigated the breast cancer experience among women in Michigan exposed to brominated flame retardants, some 30years following exposure. Michigan residents were enrolled in a study cohort after exposure to polybrominated biphenyls (PBBs) through the consumption of contaminated food products. PBB concentrations were measured in serum at the time of enrolment. Cancer experience was determined by linkage to the Michigan Cancer Registry. We conducted a nested case-control study that included 51 women diagnosed with breast cancer during 1974-2004 and 202 age-matched controls. While the data suggest an increase in breast cancer risk with higher PBB exposure, this did not reach statistical significance. The OR of having breast cancer among women with PBB concentrations ≥10ng/mL compared to women with PBB concentrations at or below the limit of detection of 1ng/mL was 2.60, 95% CI 0.93 to 7.27, (p=0.07), when adjusted for age and family history of cancer in a first-degree female relative. It remains important to examine exposure to brominated chemicals and possible health effects, and to continue following the cancer experience of participants in this study.
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U2 - 10.1136/oemed-2015-103458
DO - 10.1136/oemed-2015-103458
M3 - Article
C2 - 27312402
AN - SCOPUS:84979060344
VL - 73
SP - 564
EP - 567
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
SN - 1351-0711
IS - 8
ER -