Breast cancer among women in Michigan following exposure to brominated flame retardants

Metrecia L. Terrell, Karin A. Rosenblatt, Julie Wirth, Lorraine L. Cameron, Michele Marcus

Research output: Contribution to journalArticlepeer-review


In this updated follow-up, we investigated the breast cancer experience among women in Michigan exposed to brominated flame retardants, some 30years following exposure. Michigan residents were enrolled in a study cohort after exposure to polybrominated biphenyls (PBBs) through the consumption of contaminated food products. PBB concentrations were measured in serum at the time of enrolment. Cancer experience was determined by linkage to the Michigan Cancer Registry. We conducted a nested case-control study that included 51 women diagnosed with breast cancer during 1974-2004 and 202 age-matched controls. While the data suggest an increase in breast cancer risk with higher PBB exposure, this did not reach statistical significance. The OR of having breast cancer among women with PBB concentrations ≥10ng/mL compared to women with PBB concentrations at or below the limit of detection of 1ng/mL was 2.60, 95% CI 0.93 to 7.27, (p=0.07), when adjusted for age and family history of cancer in a first-degree female relative. It remains important to examine exposure to brominated chemicals and possible health effects, and to continue following the cancer experience of participants in this study.

Original languageEnglish (US)
Pages (from-to)564-567
Number of pages4
JournalOccupational and Environmental Medicine
Issue number8
StatePublished - Aug 2016

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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