Bovine kobuvirus - a comprehensive review

Lili Hao, Chaoxi Chen, Keith Bailey, Leyi Wang

Research output: Contribution to journalReview articlepeer-review


Bovine kobuvirus (BKV) is a single-stranded, positive sense, non-enveloped RNA virus in genus Kobuvirus of family Picornavirus. BKV was first identified in the culture media of HeLa cell containing calf serum in 2003. Since then, BKV has been detected in 13 countries of four different continents, suggesting widespread in the world. Herein, we review the detection and genomic characterization of BKV in 13 countries. All studies tested bovine fecal samples for BKV. These studies provide evidence that BKV might be a causative agent for neonatal calf diarrhea. Therefore, further efforts including animal challenge study are urgently needed to unveil the pathogenicity of BKV.

Original languageEnglish (US)
Pages (from-to)1886-1894
Number of pages9
JournalTransboundary and Emerging Diseases
Issue number4
Early online dateNov 3 2020
StatePublished - Jul 2021


  • bovine kobuvirus
  • detection
  • genomic sequence
  • rRT-PCR
  • RT-PCR

ASJC Scopus subject areas

  • General Veterinary
  • General Immunology and Microbiology


Dive into the research topics of 'Bovine kobuvirus - a comprehensive review'. Together they form a unique fingerprint.

Cite this