Botulinum toxin C3 inhibits hyperalgesia in mice with partial sciatic nerve injury

Xun Ye, Makoto Inoue, Hiroshi Ueda

Research output: Contribution to journalArticle

Abstract

Mice with partial ligation of the sciatic nerve exhibited marked increase in the second phase nociceptive biting and licking behavior following intraplantar injection of formalin. The intrathecal pretreatment with botulinum toxin C3 dose-dependently attenuated the hyperalgesia in the second phase. These results suggest that a small G protein, Rho and its downstream mechanisms are involved in the hyperalgesia following partial nerve injury.

Original languageEnglish (US)
Pages (from-to)161-163
Number of pages3
JournalJapanese Journal of Pharmacology
Volume83
Issue number2
DOIs
StatePublished - Jul 24 2000
Externally publishedYes

Keywords

  • Botulinum toxin C3
  • Hyperalgesia
  • Sciatic nerve injury

ASJC Scopus subject areas

  • Pharmacology

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