Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand

Hang Xing, Yugang Bai, Yunhao Bai, Li Huey Tan, Jing Tao, Benjamin Pedretti, Gretchen A. Vincil, Yi Lu, Steven C. Zimmerman

Research output: Contribution to journalArticle

Abstract

We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve its functions.

Original languageEnglish (US)
Pages (from-to)3623-3626
Number of pages4
JournalJournal of the American Chemical Society
Volume139
Issue number10
DOIs
StatePublished - Mar 15 2017

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand'. Together they form a unique fingerprint.

  • Cite this