"Bottom-up" approach for implementing nano/microstructure using biological and chemical interactions

Sang Woo Lee, Woo Jin Chang, Rashid Bashir, Yoon Mo Koo

Research output: Contribution to journalReview articlepeer-review


The "Bottom-up" approach for implementing nano/microstructure using biological self-assembled systems has been investigated with tremendous interest by many researchers in the field of medical diagnostics, material synthesis, and nano/microelectronics. As a result, the techniques for achieving these systems have been extensively explored in recent years. The developed or developing techniques are based on many interdisciplinary areas such as biology, chemistry, physics, electrical engineering, mechanical engineering, and so on. In this paper, we review the fundamentals behind the self-assembly concepts and describe the state of art in the biological and chemical self-assembled systems for the implementation of nano/microstructures. These structures described in the paper can be applied to the implementation of hybrid bio-sensors, biochip, novel bio-mimetic materials, and nano/microelectronic devices.

Original languageEnglish (US)
Pages (from-to)185-199
Number of pages15
JournalBiotechnology and Bioprocess Engineering
Issue number3
StatePublished - May 2007
Externally publishedYes


  • Biomolecules
  • Bottom-up implementation
  • Nano/microstructures
  • Self-assembly

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Biomedical Engineering


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