Born approximation model for light scattering by red blood cells

Joonoh Lim, Huafeng Ding, Mustafa Mir, Ruoyu Zhu, Krishnarao Tangella, Gabriel Popescu

Research output: Contribution to journalArticlepeer-review

Abstract

The primary role of a red blood cell (RBC) is delivering oxygen throughout our body. Abnormalities of this basic function lead to anemia and are caused by numerous diseases such as malaria and sickle cell anemia. As prompt and inexpensive tests for blood screening are in demand, we have developed a faster and reliable way to measure morphological parameters associated with the structure of red blood cells and the size distribution of the cells in a whole blood smear. Modeling the RBC shape under Born approximation, we are able to determine parameters of clinical relevance, such as the diameter, thickness and dimple size. From a measured quantitative phase image of a blood smear, we can determine the average and standard deviation of the red blood cell volume simultaneously, i.e., without analyzing each cell individually. This approach may open the door for a new generation of label-free, high-throughput blood testing.

Original languageEnglish (US)
Pages (from-to)2784-2791
Number of pages8
JournalBiomedical Optics Express
Volume2
Issue number10
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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