TY - JOUR
T1 - Born approximation model for light scattering by red blood cells
AU - Lim, Joonoh
AU - Ding, Huafeng
AU - Mir, Mustafa
AU - Zhu, Ruoyu
AU - Tangella, Krishnarao
AU - Popescu, Gabriel
PY - 2011
Y1 - 2011
N2 - The primary role of a red blood cell (RBC) is delivering oxygen throughout our body. Abnormalities of this basic function lead to anemia and are caused by numerous diseases such as malaria and sickle cell anemia. As prompt and inexpensive tests for blood screening are in demand, we have developed a faster and reliable way to measure morphological parameters associated with the structure of red blood cells and the size distribution of the cells in a whole blood smear. Modeling the RBC shape under Born approximation, we are able to determine parameters of clinical relevance, such as the diameter, thickness and dimple size. From a measured quantitative phase image of a blood smear, we can determine the average and standard deviation of the red blood cell volume simultaneously, i.e., without analyzing each cell individually. This approach may open the door for a new generation of label-free, high-throughput blood testing.
AB - The primary role of a red blood cell (RBC) is delivering oxygen throughout our body. Abnormalities of this basic function lead to anemia and are caused by numerous diseases such as malaria and sickle cell anemia. As prompt and inexpensive tests for blood screening are in demand, we have developed a faster and reliable way to measure morphological parameters associated with the structure of red blood cells and the size distribution of the cells in a whole blood smear. Modeling the RBC shape under Born approximation, we are able to determine parameters of clinical relevance, such as the diameter, thickness and dimple size. From a measured quantitative phase image of a blood smear, we can determine the average and standard deviation of the red blood cell volume simultaneously, i.e., without analyzing each cell individually. This approach may open the door for a new generation of label-free, high-throughput blood testing.
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U2 - 10.1364/BOE.2.002784
DO - 10.1364/BOE.2.002784
M3 - Article
C2 - 22025984
AN - SCOPUS:84861949589
VL - 2
SP - 2784
EP - 2791
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 10
ER -