Bont responsive hydrogels as sensors in microchannels

Kyle Plunkett, Jaisree Moorthy, William Tepp, Kimberly Berkowski, Eric Johnson, Jeffrey Moore, David Beebe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hybrid hydrogel consisting of peptide cross-linker was developed. The hydrogel was photopolymerized to form 3D posts inside a microfluidic channel. The peptide used is a substrate for botulinum neurotoxin. In preliminary studies, the hydrogel structure was shown to be degraded in the presence of the toxin, thus acting as a biosensor. The rate and extent of degradation was tuned by changing the cross-link density of the hydrogel.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages295-297
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
Country/TerritoryUnited States
CityBoston, MA
Period10/9/0510/13/05

Keywords

  • Hybrid hydrogel
  • Peptide cross-linker
  • Photopolymerization
  • Toxin enzymes detection

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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