Bont responsive hydrogels as sensors in microchannels

Kyle Plunkett, Jaisree Moorthy, William Tepp, Kimberly Berkowski, Eric Johnson, Jeffrey Moore, David Beebe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hybrid hydrogel consisting of peptide cross-linker was developed. The hydrogel was photopolymerized to form 3D posts inside a microfluidic channel. The peptide used is a substrate for botulinum neurotoxin. In preliminary studies, the hydrogel structure was shown to be degraded in the presence of the toxin, thus acting as a biosensor. The rate and extent of degradation was tuned by changing the cross-link density of the hydrogel.

Original languageEnglish (US)
Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference
Subtitle of host publication9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherTransducer Research Foundation
Pages295-297
Number of pages3
ISBN (Print)0974361119, 9780974361116
StatePublished - Jan 1 2005
Event9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005 - Boston, MA, United States
Duration: Oct 9 2005Oct 13 2005

Publication series

NameMicro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Volume1

Other

Other9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2005
CountryUnited States
CityBoston, MA
Period10/9/0510/13/05

Keywords

  • Hybrid hydrogel
  • Peptide cross-linker
  • Photopolymerization
  • Toxin enzymes detection

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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