Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives

Antalya Ho-Shui-Ling, Johanna Bolander, Laurence E. Rustom, Amy Jaye Wagoner Johnson, Frank P. Luyten, Catherine Picart

Research output: Contribution to journalReview article

Abstract

Bone fractures are the most common traumatic injuries in humans. The repair of bone fractures is a regenerative process that recapitulates many of the biological events of embryonic skeletal development. Most of the time it leads to successful healing and the recovery of the damaged bone. Unfortunately, about 5–10% of fractures will lead to delayed healing or non-union, more so in the case of co-morbidities such as diabetes. In this article, we review the different strategies to heal bone defects using synthetic bone graft substitutes, biologically active substances and stem cells. The majority of currently available reviews focus on strategies that are still at the early stages of development and use mostly in vitro experiments with cell lines or stem cells. Here, we focus on what is already implemented in the clinics, what is currently in clinical trials, and what has been tested in animal models. Treatment approaches can be classified in three major categories: i) synthetic bone graft substitutes (BGS) whose architecture and surface can be optimized; ii) BGS combined with bioactive molecules such as growth factors, peptides or small molecules targeting bone precursor cells, bone formation and metabolism; iii) cell-based strategies with progenitor cells combined or not with active molecules that can be injected or seeded on BGS for improved delivery. We review the major types of adult stromal cells (bone marrow, adipose and periosteum derived) that have been used and compare their properties. Finally, we discuss the remaining challenges that need to be addressed to significantly improve the healing of bone defects.

Original languageEnglish (US)
Pages (from-to)143-162
Number of pages20
JournalBiomaterials
Volume180
DOIs
StatePublished - Oct 2018

Fingerprint

Bone Substitutes
Bone Regeneration
Stem cells
Scaffolds
Bone
Stem Cells
Transplants
Bone and Bones
Molecules
Bone Fractures
Grafts
Periosteum
Mesenchymal Stromal Cells
Osteogenesis
Embryonic Development
Intercellular Signaling Peptides and Proteins
Animal Models
Clinical Trials
Morbidity
Cell Line

Keywords

  • Bioactive
  • Biomaterial
  • Fracture
  • Nonunion
  • Scaffold
  • Stem cells

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Bone regeneration strategies : Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives. / Ho-Shui-Ling, Antalya; Bolander, Johanna; Rustom, Laurence E.; Wagoner Johnson, Amy Jaye; Luyten, Frank P.; Picart, Catherine.

In: Biomaterials, Vol. 180, 10.2018, p. 143-162.

Research output: Contribution to journalReview article

Ho-Shui-Ling, Antalya ; Bolander, Johanna ; Rustom, Laurence E. ; Wagoner Johnson, Amy Jaye ; Luyten, Frank P. ; Picart, Catherine. / Bone regeneration strategies : Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives. In: Biomaterials. 2018 ; Vol. 180. pp. 143-162.
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