Bone Mineral Content Estimation in People Living with HIV: Prediction and Validation of Sex-Specific Anthropometric Models

Igor Massari Correia, Anderson Marliere Navarro, Jéssica Fernanda Corrêa Cordeiro, Euripedes Barsanulfo Gonçalves Gomide, Lisa Fernanda Mazzonetto, Alcivandro de Sousa Oliveira, Emerson Sebastião, Bruno Augusto Aguilar, Denise de Andrade, Dalmo Roberto Lopes Machado, André Pereira dos Santos

Research output: Contribution to journalArticlepeer-review


People living with HIV (PWH) experience an accelerated reduction in bone mineral content (BMC), and a high risk of osteopenia and osteoporosis. Anthropometry is an accurate and low-cost method that can be used to monitor changes in body composition in PWH. To date, no studies have used anthropometry to estimate BMC in PWH. To propose and validate sex-specific anthropometric models to predict BMC in PWH. This cross-sectional study enrolled 104 PWH (64 males) aged >18 years at a local university hospital. BMC was measured using dual energy X-ray absorptiometry (DXA). Anthropometric measures were collected. We used linear regression analysis to generate the models. Cross-validations were conducted using the “leave one out”, from the predicted residual error sum of squares (PRESS) method. Bland–Altman plots were used to explore distributions of errors. We proposed models with high coefficient of determination and reduced standard error of estimate for males (r2 = 0.70; SEE = 199.97 g; Q2PRESS = 0.67; SEEPRESS = 208.65 g) and females (r2 = 0.65; SEE = 220.96 g; Q2PRESS = 0.62; SEEPRESS = 221.90 g). Our anthropometric predictive models for BMC are valid, practical, and a low-cost alternative to monitoring bone health in PWH.

Original languageEnglish (US)
Article number12336
JournalInternational journal of environmental research and public health
Issue number19
StatePublished - Oct 2022
Externally publishedYes


  • acquired immunodeficiency syndrome
  • aging
  • bone density
  • osteoporosis

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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