Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: Repeatability and effect of genetic selection

J. S. Rhodes, P. Koteja, J. G. Swallow, P. A. Carter, T. Garland

Research output: Contribution to journalArticlepeer-review

Abstract

We studied rectal body temperatures of house mice (Mus domesticus) that had been artificially selected for high voluntary wheel running. 1. At generation 17, mice from the four replicate selected lines ran, on average, 2.5-times as many revolutions/day as did mice from the four random-bred control lines. 2. During the day, repeatability of individual differences in body temperature measured 4 days apart was low; at night, repeatability was statistically significant across three time scales (1 day, 1 week, 2 weeks). 3. During the day, body temperatures of selected and control animals did not differ; at night, mice from selected' lines had higher body temperatures. However, when amount of wheel running immediately prior to measurement was included as a covariate, the difference was no longer statistically significant. Higher body temperatures, associated with increased activity, might enhance locomotor abilities through Q10 effects; increase metabolic rate and food requirements, affect sleep patterns, and alter expression of heat-shock proteins. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)391-400
Number of pages10
JournalJournal of Thermal Biology
Volume25
Issue number5
DOIs
StatePublished - Oct 1 2000
Externally publishedYes

Keywords

  • Artificial selection
  • Evolutionary physiology
  • Locomotion
  • Motor activity
  • Mus domesticus
  • Quantitative genetics
  • Repeatability
  • Wheel running

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Agricultural and Biological Sciences(all)
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: Repeatability and effect of genetic selection'. Together they form a unique fingerprint.

Cite this