Blood flow mechanics in cardiovascular development

Francesco Boselli, Jonathan B. Freund, Julien Vermot

Research output: Contribution to journalReview article

Abstract

Hemodynamic forces are fundamental to development. Indeed, much of cardiovascular morphogenesis reflects a two-way interaction between mechanical forces and the gene network activated in endothelial cells via mechanotransduction feedback loops. As these interactions are becoming better understood in different model organisms, it is possible to identify common mechanogenetic rules, which are strikingly conserved and shared in many tissues and species. Here, we discuss recent findings showing how hemodynamic forces potentially modulate cardiovascular development as well as the underlying fluid and tissue mechanics, with special attention given to the flow characteristics that are unique to the small scales of embryos.

Original languageEnglish (US)
Pages (from-to)2545-2559
Number of pages15
JournalCellular and Molecular Life Sciences
Volume72
Issue number13
DOIs
StatePublished - Jul 8 2015

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Biomechanics
  • Cardiomyopathy
  • Fluid mechanics
  • Klf2
  • Valvulopathie

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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