Bisphosphonates Are Potent Inhibitors of Trypanosoma cruzi Farnesyl Pyrophosphate Synthase

Keyphrases

• Potent Inhibitor 100%
• Bisphosphonates 100%
• Trypanosoma Cruzi (T. cruzi) 100%
• Geranylgeranyl Diphosphate Synthase 100%
• Nitrogen-containing Bisphosphonates 66%
• Amino Acids 16%
• Active Sites 16%
• Escherichia Coli 16%
• Nucleotide Sequence 16%
• Reactive Intermediates 16%
• Transition State 16%
• Molecular Mass 16%
• Heterologous Expression 16%
• Drug Development 16%
• Sequence Motif 16%
• Bifunctional Enzyme 16%
• Sequence Difference 16%
• Bone Resorption 16%
• Carbocations 16%
• Parasite Growth 16%
• Alendronate 16%
• Risedronate 16%
• Etidronate 16%
• Antichagasic Agent 16%

Biochemistry, Genetics and Molecular Biology

• Synthase 100%
• Trypanosoma Cruzi 100%
• Farnesyl Pyrophosphate 100%
• Amino Acids 20%
• Nucleotide Sequence 20%
• Active Site 20%
• Molecular Weight 20%
• Enzyme 20%
• Escherichia coli 20%
• Heterologous Expression 20%
• Osteolysis 20%
• Sequence Motif 20%