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Bisphosphonates Are Potent Inhibitors of Trypanosoma cruzi Farnesyl Pyrophosphate Synthase
Andrea Montalvetti
, Brian N. Bailey
, Michael B. Martin
, Gregory W. Severin
,
Eric Oldfield
, Roberto Docampo
Chemistry
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Keyphrases
Potent Inhibitor
100%
Bisphosphonates
100%
Trypanosoma Cruzi (T. cruzi)
100%
Geranylgeranyl Diphosphate Synthase
100%
Nitrogen-containing Bisphosphonates
66%
Amino Acids
16%
Active Sites
16%
Escherichia Coli
16%
Nucleotide Sequence
16%
Reactive Intermediates
16%
Transition State
16%
Molecular Mass
16%
Heterologous Expression
16%
Drug Development
16%
Sequence Motif
16%
Bifunctional Enzyme
16%
Sequence Difference
16%
Bone Resorption
16%
Carbocations
16%
Parasite Growth
16%
Alendronate
16%
Risedronate
16%
Etidronate
16%
Antichagasic Agent
16%
Biochemistry, Genetics and Molecular Biology
Synthase
100%
Trypanosoma Cruzi
100%
Farnesyl Pyrophosphate
100%
Amino Acids
20%
Nucleotide Sequence
20%
Active Site
20%
Molecular Weight
20%
Enzyme
20%
Escherichia coli
20%
Heterologous Expression
20%
Osteolysis
20%
Sequence Motif
20%