Biotransformation of the mycotoxin enniatin b1 by CYP P450 3A4 and potential for drug-drug interactions

Keyphrases

• Mycotoxins 100%
• Drug Interactions 100%
• Biotransformation 100%
• CYP P450 100%
• Enniatins 100%
• P450 3A4 100%
• Cytochrome P450 3A4 (CYP3A4) 80%
• Deoxynivalenol 60%
• Nanodiscs 40%
• Human Liver Microsomes 40%
• Active Sites 20%
• In Vitro System 20%
• Conformational Change 20%
• Progesterone 20%
• Oxidation Reaction 20%
• Kinetic Characteristics 20%
• Metabolic Enzymes 20%
• Lipophilicity 20%
• CYP3A4 Substrates 20%
• Formation Rate 20%
• Hydroxylation 20%
• Interaction Studies 20%
• Cytochrome P450 3A (CYP3A) 20%
• Natural Toxins 20%
• Characteristic Potentials 20%
• Midazolam 20%
• Temperate Climate 20%
• Metabolite Formation 20%
• Inhibitory Potential 20%
• Biotransformation Pathway 20%
• Antifungal Metabolites 20%
• Toxic Potency 20%
• Atorvastatin Lactone 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Mycotoxin 100%
• CYP3A4 100%
• Cytochrome P450 100%
• Drug-Drug Interaction 100%
• Enniatin 100%
• Vomitoxin 60%
• Nanodisc 40%
• Lactone 20%
• Atorvastatin 20%
• Digestant 20%
• Progesterone 20%
• CYP3A 20%
• Lipophilicity 20%
• Midazolam 20%
• Natural Toxin 20%

Immunology and Microbiology

• Biotransformation 100%
• Drug-Drug Interaction 100%
• Metabolite 66%
• Liver Microsome 66%
• Conformational Transition 33%
• Secondary Metabolite 33%
• Hydroxylation 33%
• Lipophilicity 33%
• Cytochrome P450 33%