Biosynthesis of parathyroid hormone

Much additional information about the nature of the normal controlling processes within the parathyroid cell involved in regulation between initial step of ProPTH synthesis and eventual release of PTH from storage granules is needed. Such information will be of great fundamental interest in the general area of biosynthesis of proteins destined for secretion from the cell. The parathyroid system may eventually serve as a model with which to evaluate, on cellular and biochemical level, the failure of homeostatic mechanisms involved is neoplasia or hyperplasia of the parathyroids. The studies may, in turn, facilitate more discriminant diagnoses based on specific immunoassays for the various secretory products defined by present investigations.