Biosensing with DNAzymes

Erin M. McConnell, Ioana Cozma, Quanbing Mou, John D. Brennan, Yi Lu, Yingfu Li

Research output: Contribution to journalReview articlepeer-review


This article provides a comprehensive review of biosensing with DNAzymes, providing an overview of different sensing applications while highlighting major progress and seminal contributions to the field of portable biosensor devices and point-of-care diagnostics. Specifically, the field of functional nucleic acids is introduced, with a specific focus on DNAzymes. The incorporation of DNAzymes into bioassays is then described, followed by a detailed overview of recent advances in the development of in vivo sensing platforms and portable sensors incorporating DNAzymes for molecular recognition. Finally, a critical perspective on the field, and a summary of where DNAzyme-based devices may make the biggest impact are provided.

Original languageEnglish (US)
Pages (from-to)8954-8994
Number of pages41
JournalChemical Society Reviews
Issue number16
StatePublished - Aug 21 2021

ASJC Scopus subject areas

  • General Chemistry

Cite this