Using the optically resonant surfaces of photonic crystals and plasmonic crystals, we demonstrate the design and application of a new class of label-free optical biosensors that utilize the stimulated emission process associated with an external cavity laser to achieve high resolution, while retaining the high wavelength shift sensitivity. The External Cavity Laser (ECL) biosensor approach has been applied to direct detection of small molecule interactions with immobilized proteins in the context of high throughput drug screening, using a novel self-referencing approach that accurately compensates for the effects of thermal drift and bulk refractive index variation.

Original languageEnglish (US)
Title of host publicationOptical Sensors, Sensors 2015
PublisherOptical Society of America (OSA)
ISBN (Print)9781557520005
StatePublished - 2015
EventOptical Sensors, Sensors 2015 - Boston, United States
Duration: Jun 27 2015Jul 1 2015

Publication series

NameOptical Sensors, Sensors 2015


OtherOptical Sensors, Sensors 2015
Country/TerritoryUnited States

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Hardware and Architecture


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