Biosensing based on surface-enhanced raman spectroscopy

Gang Logan Liu, Wenwei Zheng, Pingping Zhang, Fanqing Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In view of basic science, to understand biological systems increasingly depends on our ability to dynamically and quantitatively measure the molecular processes with high sensitivity, speed, exibility, multiplexity, throughput, and reproducibility, usually within the context of a complex biological and chemical mixture of a tiny amount. A living cell responds to its changing environment both inside and outside itself in such a dynamic way that hundreds and thousands of signaling proteins, enzymes, siRNA, DNA, mRNA, and transcription and translation factors are constantly modied or synthesized, transferred from one organelle to another, and perform appropriate cell functions in macromolecule complexes, behaving like an army of molecular machines working in perfect synchronicity and harmony. These biomolecular complexes are not only heterogeneously distributed, recombined, modied, and reassembled continuously, but perpetually changed over time with the change of surrounding microenvironments [1]. To quantitatively follow the biochemical reactions within multimolecule complexes, it is vital for the general goal of intimately following the molecular machines in cell signaling, growth, differentiation, apoptosis, cell developmental processes, and relevant diseases. In the biotechnology industry, combinatorial methods are increasingly applied to synthesize new biocatalysts or drugs, demanding the simultaneous analysis of thousands of pathogens, mutants, drug target enzymes, or therapeutic drugs themselves. Furthermore, in personalized medicine, as dictated by economic reasons, the mass application of screening and diagnostic tools have to be fast, convenient, and low cost, requiring the miniaturization, parallelization, integration, as well as automation of biosensing devices.

Original languageEnglish (US)
Title of host publicationBiosensors Based on Nanomaterials and Nanodevices
EditorsJun Li, Nianqiang Wu
PublisherCRC Press
Pages111-155
Number of pages45
ISBN (Electronic)9781466551527
ISBN (Print)9781466551510
DOIs
StatePublished - Jan 1 2017

Fingerprint

Raman Spectrum Analysis
Raman spectroscopy
drugs
Enzymes
Cell signaling
Biocatalysts
enzymes
Pathogens
Cell death
Biological systems
Transcription
Biotechnology
cells
Macromolecules
Pharmaceutical Preparations
Medicine
Miniaturization
costs
Precision Medicine
Screening

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Liu, G. L., Zheng, W., Zhang, P., & Chen, F. (2017). Biosensing based on surface-enhanced raman spectroscopy. In J. Li, & N. Wu (Eds.), Biosensors Based on Nanomaterials and Nanodevices (pp. 111-155). CRC Press. https://doi.org/10.1201/b16234-7

Biosensing based on surface-enhanced raman spectroscopy. / Liu, Gang Logan; Zheng, Wenwei; Zhang, Pingping; Chen, Fanqing.

Biosensors Based on Nanomaterials and Nanodevices. ed. / Jun Li; Nianqiang Wu. CRC Press, 2017. p. 111-155.

Research output: Chapter in Book/Report/Conference proceedingChapter

Liu, GL, Zheng, W, Zhang, P & Chen, F 2017, Biosensing based on surface-enhanced raman spectroscopy. in J Li & N Wu (eds), Biosensors Based on Nanomaterials and Nanodevices. CRC Press, pp. 111-155. https://doi.org/10.1201/b16234-7
Liu GL, Zheng W, Zhang P, Chen F. Biosensing based on surface-enhanced raman spectroscopy. In Li J, Wu N, editors, Biosensors Based on Nanomaterials and Nanodevices. CRC Press. 2017. p. 111-155 https://doi.org/10.1201/b16234-7
Liu, Gang Logan ; Zheng, Wenwei ; Zhang, Pingping ; Chen, Fanqing. / Biosensing based on surface-enhanced raman spectroscopy. Biosensors Based on Nanomaterials and Nanodevices. editor / Jun Li ; Nianqiang Wu. CRC Press, 2017. pp. 111-155
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