Biomimetic triphasic scaffolds for osteotendinous junction regeneration

Raul A. Sun Han Chang, Ching Wei Lee, Simon Rogers, Brendan A Harley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: The osteotendinous junction links tendon to bone via a continuous fibrocartilaginous interface (enthesis) that reduces interfacial strain and decreases the risk of failure between highly elastic tendon and 100-fold stiffer bone.1 Osteotendinous injuries can take place via acute (e.g. overload) or degradative (e.g. aging) processes. Surgical interventions that mechanically fix the torn tendon to bone result in poor healing of the native enthesis and high re-failure rates.2 Functional reintegration of the torn tissues requires regeneration of the compliant fibrocartilaginous interface. Progress towards regenerating the tendon-to-bone enthesis is hampered by an inability for biomaterials to present spatially continuous interface zones or to overcome high levels of local strain that form at the interface between dissimilar tissues. We describe a triphasic biomaterial comprising osseous and tendinous collagen-GAG (CG) scaffold zones integrated via a compliant polyethylene glycol (PEG) hydrogel seam. We report tuning biomaterial properties by varying the gelation rate and stiffness of the hydrogel seam to control the topology of the interface and resultant mechanical properties and deformation under tensile load. The flanking CG zones promote region-specific osteogenic and tenogenic behavior in human mesenchymal stem cells (hMSCs)3, and the interfacial hydrogel seam grants a platform to explicitly address interface remodeling. Individually, these compartments address local cell response using tissue-relevant matrix structural cues, and together form a continuous scaffold that mimics the physical behavior of osteotendinous tissue.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Sun Han Chang, R. A., Lee, C. W., Rogers, S., & Harley, B. A. (2019). Biomimetic triphasic scaffolds for osteotendinous junction regeneration. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.