TY - GEN
T1 - Biomedical nanotechnology for molecular imaging, profiling, and drug targeting
AU - Kim, Gloria J.
AU - O'Regan, Ruth M.
AU - Nie, Shuming
PY - 2005
Y1 - 2005
N2 - Nanometer-sized particles have novel optical, electronic, and structural properties that are not available from either individual molecules or bulk solids. When linked with tumor targeting ligands such as monoclonal antibodies, these nanoparticles can be used to target tumor antigens (biomarkers) as well as tumor vasculatures with high affinity and specificity. In the "mesoscopic" size range of 10-100 nm (diameter), nanoparticles also have more surface areas and functional groups that can be linked to multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic (e.g., anticancer) agents. In this article, we briefly discuss the use of bioconjugated nanoparticles for delivery and targeting of anticancer drugs.
AB - Nanometer-sized particles have novel optical, electronic, and structural properties that are not available from either individual molecules or bulk solids. When linked with tumor targeting ligands such as monoclonal antibodies, these nanoparticles can be used to target tumor antigens (biomarkers) as well as tumor vasculatures with high affinity and specificity. In the "mesoscopic" size range of 10-100 nm (diameter), nanoparticles also have more surface areas and functional groups that can be linked to multiple diagnostic (e.g., optical, radioisotopic, or magnetic) and therapeutic (e.g., anticancer) agents. In this article, we briefly discuss the use of bioconjugated nanoparticles for delivery and targeting of anticancer drugs.
UR - http://www.scopus.com/inward/record.url?scp=33846930871&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846930871&partnerID=8YFLogxK
U2 - 10.1109/iembs.2005.1616513
DO - 10.1109/iembs.2005.1616513
M3 - Conference contribution
AN - SCOPUS:33846930871
SN - 0780387406
SN - 9780780387409
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
SP - 714
EP - 716
BT - Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Y2 - 1 September 2005 through 4 September 2005
ER -