Abstract
The conversion of mechanical stimuli into chemical signals is of the utmost importance for developmental and normal physiology. Mechanotransduction plays a pivotal role in regulating cellular function and, subsequent tissue maintenance and repair, apoptosis, and many other physiological functions, coupled with a broad array of soluble factors. The successful examination of how mechanotransduction effects cells' function, in vitro, requires the ability to develop cell culture platforms that recapitulate extracellular environments in which the cells reside. Recently, significant progress in biomaterial design has allowed the examination of the effects mechanotransduction plays on a broad array of extracellular microenvironments. This chapter will review a series of biomaterials used for mechanotransduction studies specifically focusing on glass substrates, poly(dimethyl siloxane) (PDMS) and polymeric hydrogels, and also discuss strategies for designing advanced biomaterial systems.
| Original language | English (US) |
|---|---|
| Title of host publication | Mechanobiology of Cell-Cell and Cell-Matrix Interactions |
| Publisher | Springer US |
| Pages | 267-277 |
| Number of pages | 11 |
| ISBN (Print) | 9781441980823 |
| DOIs | |
| State | Published - Dec 1 2011 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Biomaterials for studies in cellular mechanotransduction. / De Volder, Ross; Kong, Hyunjoon.
Mechanobiology of Cell-Cell and Cell-Matrix Interactions. Springer US, 2011. p. 267-277.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Biomaterials for studies in cellular mechanotransduction
AU - De Volder, Ross
AU - Kong, Hyunjoon
PY - 2011/12/1
Y1 - 2011/12/1
N2 - The conversion of mechanical stimuli into chemical signals is of the utmost importance for developmental and normal physiology. Mechanotransduction plays a pivotal role in regulating cellular function and, subsequent tissue maintenance and repair, apoptosis, and many other physiological functions, coupled with a broad array of soluble factors. The successful examination of how mechanotransduction effects cells' function, in vitro, requires the ability to develop cell culture platforms that recapitulate extracellular environments in which the cells reside. Recently, significant progress in biomaterial design has allowed the examination of the effects mechanotransduction plays on a broad array of extracellular microenvironments. This chapter will review a series of biomaterials used for mechanotransduction studies specifically focusing on glass substrates, poly(dimethyl siloxane) (PDMS) and polymeric hydrogels, and also discuss strategies for designing advanced biomaterial systems.
AB - The conversion of mechanical stimuli into chemical signals is of the utmost importance for developmental and normal physiology. Mechanotransduction plays a pivotal role in regulating cellular function and, subsequent tissue maintenance and repair, apoptosis, and many other physiological functions, coupled with a broad array of soluble factors. The successful examination of how mechanotransduction effects cells' function, in vitro, requires the ability to develop cell culture platforms that recapitulate extracellular environments in which the cells reside. Recently, significant progress in biomaterial design has allowed the examination of the effects mechanotransduction plays on a broad array of extracellular microenvironments. This chapter will review a series of biomaterials used for mechanotransduction studies specifically focusing on glass substrates, poly(dimethyl siloxane) (PDMS) and polymeric hydrogels, and also discuss strategies for designing advanced biomaterial systems.
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UR - http://www.scopus.com/inward/citedby.url?scp=84895013393&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-8083-0_12
DO - 10.1007/978-1-4419-8083-0_12
M3 - Chapter
AN - SCOPUS:84895013393
SN - 9781441980823
SP - 267
EP - 277
BT - Mechanobiology of Cell-Cell and Cell-Matrix Interactions
PB - Springer US
ER -