TY - JOUR
T1 - Biomaterials for enhancing neuronal repair
AU - Cangellaris, Olivia V.
AU - Gillette, Martha U.
N1 - Funding Information:
The authors acknowledge funding from the Medical Scholars Program at the University of Illinois and Christie Foundation Award (OVC), and the National Science Foundation STC Emergent Behaviors of Integrated Cellular Systems CBET 0939511 (MUG).
Funding Information:
The authors thank Guillermo L. Monroy for contributions to revising the manuscript, Jennifer W. Mitchell for insights in figure preparation, and Ann C. Benefiel for facilitating manuscript submission. The authors thank Xiuling Li, Paul Froeter, and Hyun Joon Kong (University of Illinois at Urbana-Champaign), and John A. Rogers (Northwestern University) for providing images. Funding. The authors acknowledge funding from the Medical Scholars Program at the University of Illinois and Christie Foundation Award (OVC), and the National Science Foundation STC Emergent Behaviors of Integrated Cellular Systems CBET 0939511 (MUG).
Publisher Copyright:
© 2018 Cangellaris and Gillette.
PY - 2018/4/10
Y1 - 2018/4/10
N2 - As they differentiate from neuroblasts, nascent neurons become highly polarized and elongate. Neurons extend and elaborate fine and fragile cellular extensions that form circuits enabling long-distance communication and signal integration within the body. While other organ systems are developing, projections of differentiating neurons find paths to distant targets. Subsequent post-developmental neuronal damage is catastrophic because the cues for reinnervation are no longer active. Advances in biomaterials are enabling fabrication of micro-environments that encourage neuronal regrowth and restoration of function by recreating these developmental cues. This mini-review considers new materials that employ topographical, chemical, electrical, and/or mechanical cues for use in neuronal repair. Manipulating and integrating these elements in different combinations will generate new technologies to enhance neural repair.
AB - As they differentiate from neuroblasts, nascent neurons become highly polarized and elongate. Neurons extend and elaborate fine and fragile cellular extensions that form circuits enabling long-distance communication and signal integration within the body. While other organ systems are developing, projections of differentiating neurons find paths to distant targets. Subsequent post-developmental neuronal damage is catastrophic because the cues for reinnervation are no longer active. Advances in biomaterials are enabling fabrication of micro-environments that encourage neuronal regrowth and restoration of function by recreating these developmental cues. This mini-review considers new materials that employ topographical, chemical, electrical, and/or mechanical cues for use in neuronal repair. Manipulating and integrating these elements in different combinations will generate new technologies to enhance neural repair.
KW - Electrical stimulation
KW - Flexible electronics
KW - Hydrogels
KW - Nerve-guide-conduits
KW - Neural scaffolds
KW - Neuroregenerative therapy
KW - Self-rolled-up membranes
KW - Topography
UR - http://www.scopus.com/inward/record.url?scp=85054831668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054831668&partnerID=8YFLogxK
U2 - 10.3389/fmats.2018.00021
DO - 10.3389/fmats.2018.00021
M3 - Short survey
AN - SCOPUS:85054831668
SN - 2296-8016
VL - 5
JO - Frontiers in Materials
JF - Frontiers in Materials
M1 - 21
ER -