Abstract

Stem cells and endothelial progenitor cells are increasingly studied for use in therapeutic angiogenesis to treat ischemic tissues and critical-sized tissue defects because of their potential to sustainably express multiple angiogenic factors and also differentiate to endothelial cells. These cells are often incorporated into a variety of biomaterials which can function as a provisional matrix to localize or deploy cells and also to regulate cellular phenotypic activities at a transplantation site. This chapter will summarize previous and current efforts to design cell-laden biomaterials in order to improve therapeutic efficacy of transplanted cells to stimulate revascularization. Finally, it will discuss future strategies of biomaterial design that can further elevate the quality of the cell-based revascularization therapy.

Original languageEnglish (US)
Title of host publicationStudies in Mechanobiology, Tissue Engineering and Biomaterials
PublisherSpringer
Pages247-259
Number of pages13
DOIs
StatePublished - Jan 1 2013

Publication series

NameStudies in Mechanobiology, Tissue Engineering and Biomaterials
Volume12
ISSN (Print)1868-2006
ISSN (Electronic)1868-2014

Keywords

  • Angiogenic Factor
  • Fibrous Scaffold
  • PLGA Scaffold
  • Porous Scaffold
  • Vascular Endothelial Growth Factor

ASJC Scopus subject areas

  • Biomedical Engineering
  • Mechanics of Materials
  • Biomaterials
  • Biotechnology
  • Biophysics
  • Medicine (miscellaneous)

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  • Cite this

    Rich, M. H., & Kong, H. (2013). Biomaterials for Cell-Based Therapeutic Angiogenesis. In Studies in Mechanobiology, Tissue Engineering and Biomaterials (pp. 247-259). (Studies in Mechanobiology, Tissue Engineering and Biomaterials; Vol. 12). Springer. https://doi.org/10.1007/978-3-642-30856-7_12