Biomaterial Scaffolds for Tendon Tissue Engineering

Rebecca Hortensius, Laura Mozdzen, Brendan Harley

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tendons are musculoskeletal tissues responsible for transmitting loads between muscle and bone. Due to their frequent injury, poor native healing, and probability of refailure following surgical intervention, there is a clinical need for alternative treatments. Biomaterial-based regenerative medicine strategies offer the potential to provide a three-dimensional microenvironment design to guide native tendon healing processes toward regenerative repair of the injured tendon with minimal scar formation. Recently, a variety of tissue engineering constructs have been developed to block the contraction and scar formation mechanisms of repair and induce regeneration following injury. Such bioactive constructs are often inspired by the native composition, structure, mechanics, and biomolecule environment, offering inspiration toward the development of constructs that mimic the extracellular matrix (ECM) of tendon. In this chapter we provide an introduction to the application of tissue engineering principles toward tendon applications. We will discuss the critical structural elements of a potential active ECM analog for tendon repair. We also discuss the importance, incorporation, and assessment of biomolecular cues, cells, and mechanical stimulation for such tendon-inspired materials. We conclude by describing current and future hurdles toward clinical translation, particularly the proper design of in vivo regeneration assays.

Original languageEnglish (US)
Title of host publicationTendon Regeneration
Subtitle of host publicationUnderstanding Tissue Physiology and Development to Engineer Functional Substitutes
PublisherElsevier Inc.
Pages349-380
Number of pages32
ISBN (Electronic)9780128016008
ISBN (Print)9780128015902
DOIs
StatePublished - Jan 1 2015

Keywords

  • Biomaterials
  • Extracellular matrix
  • Growth factors
  • Mechanical stimulation
  • Microstructure
  • Tendon
  • Tendon injury models
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Hortensius, R., Mozdzen, L., & Harley, B. (2015). Biomaterial Scaffolds for Tendon Tissue Engineering. In Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes (pp. 349-380). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801590-2.00013-2