Biological Timekeeping

Martha U. Gillette; Sabra M. Abbott

doi:10.1016/j.jsmc.2009.01.005

Biological Timekeeping

Research output: Contribution to journal › Review article › peer-review

Abstract

This article explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how various biological systems can provide input to the endogenous biological timing, and how the pacemaker can influence the physiology and behavior of the individual. It discusses how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of various inputs, including changes in light, activity, and the sleep-wake cycle. Finally, the article discusses the genetics of circadian time keeping, highlighting what is known about heritable disorders in circadian timing.

Original language	English (US)
Pages (from-to)	99-110
Number of pages	12
Journal	Sleep Medicine Clinics
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.jsmc.2009.01.005
State	Published - Jun 2009

Keywords

Acetylcholine
Advanced Sleep Phase Syndrome
Biological rhythms
Circadian
Glutamate
Melatonin
Sleep
Suprachiasmatic nucleus

ASJC Scopus subject areas

Psychiatry and Mental health
Neuropsychology and Physiological Psychology
Clinical Psychology
Clinical Neurology

Online availability

10.1016/j.jsmc.2009.01.005

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title = "Biological Timekeeping",

abstract = "This article explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how various biological systems can provide input to the endogenous biological timing, and how the pacemaker can influence the physiology and behavior of the individual. It discusses how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of various inputs, including changes in light, activity, and the sleep-wake cycle. Finally, the article discusses the genetics of circadian time keeping, highlighting what is known about heritable disorders in circadian timing.",

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AB - This article explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how various biological systems can provide input to the endogenous biological timing, and how the pacemaker can influence the physiology and behavior of the individual. It discusses how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of various inputs, including changes in light, activity, and the sleep-wake cycle. Finally, the article discusses the genetics of circadian time keeping, highlighting what is known about heritable disorders in circadian timing.

KW - Acetylcholine

KW - Advanced Sleep Phase Syndrome

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KW - Circadian

KW - Glutamate

KW - Melatonin

KW - Sleep

KW - Suprachiasmatic nucleus

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ER -

Biological Timekeeping

Abstract

Keywords

ASJC Scopus subject areas

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