Biological timekeeping

Martha U. Gillette; Sabra M. Abbott; Jennifer M. Arnold

doi:10.1016/j.jsmc.2012.06.001

Biological timekeeping

Martha U. Gillette, Sabra M. Abbott, Jennifer M. Arnold

Research output: Contribution to journal › Review article › peer-review

Abstract

This review explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how biologic systems provide input to the endogenous biologic timing, and how the pacemaker influences physiology and behavior. We discuss how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of a variety of inputs. The genetics of circadian timekeeping are discussed, highlighting what is known about heritable disorders in circadian timing and how circadian genetics have been used to study timekeeping. The role of the clock in peripheral tissues is discussed.

Original language	English (US)
Pages (from-to)	427-442
Number of pages	16
Journal	Sleep Medicine Clinics
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/j.jsmc.2012.06.001
State	Published - Sep 2012

Keywords

Biological rhythms
Circadian
Sleep
Suprachiasmatic nucleus

ASJC Scopus subject areas

Psychiatry and Mental health
Neuropsychology and Physiological Psychology
Clinical Psychology
Clinical Neurology

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10.1016/j.jsmc.2012.06.001

Cite this

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title = "Biological timekeeping",

abstract = "This review explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how biologic systems provide input to the endogenous biologic timing, and how the pacemaker influences physiology and behavior. We discuss how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of a variety of inputs. The genetics of circadian timekeeping are discussed, highlighting what is known about heritable disorders in circadian timing and how circadian genetics have been used to study timekeeping. The role of the clock in peripheral tissues is discussed.",

keywords = "Biological rhythms, Circadian, Sleep, Suprachiasmatic nucleus",

author = "Gillette, {Martha U.} and Abbott, {Sabra M.} and Arnold, {Jennifer M.}",

note = "Funding Information: This work was supported by the following past and present grants from the National Institutes of Health : HL67007 , HL086870 , HL092571Z ARRA , NS22155 , and NS35859 (MUG), F30 NS047802 and GM07143 (SMA), and GM007283 (JMA). ",

year = "2012",

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doi = "10.1016/j.jsmc.2012.06.001",

language = "English (US)",

volume = "7",

pages = "427--442",

journal = "Sleep Medicine Clinics",

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publisher = "W.B. Saunders Ltd",

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T1 - Biological timekeeping

AU - Gillette, Martha U.

AU - Abbott, Sabra M.

AU - Arnold, Jennifer M.

N1 - Funding Information: This work was supported by the following past and present grants from the National Institutes of Health : HL67007 , HL086870 , HL092571Z ARRA , NS22155 , and NS35859 (MUG), F30 NS047802 and GM07143 (SMA), and GM007283 (JMA).

PY - 2012/9

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N2 - This review explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how biologic systems provide input to the endogenous biologic timing, and how the pacemaker influences physiology and behavior. We discuss how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of a variety of inputs. The genetics of circadian timekeeping are discussed, highlighting what is known about heritable disorders in circadian timing and how circadian genetics have been used to study timekeeping. The role of the clock in peripheral tissues is discussed.

AB - This review explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how biologic systems provide input to the endogenous biologic timing, and how the pacemaker influences physiology and behavior. We discuss how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of a variety of inputs. The genetics of circadian timekeeping are discussed, highlighting what is known about heritable disorders in circadian timing and how circadian genetics have been used to study timekeeping. The role of the clock in peripheral tissues is discussed.

KW - Biological rhythms

KW - Circadian

KW - Sleep

KW - Suprachiasmatic nucleus

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DO - 10.1016/j.jsmc.2012.06.001

M3 - Review article

AN - SCOPUS:84865707222

VL - 7

SP - 427

EP - 442

JO - Sleep Medicine Clinics

JF - Sleep Medicine Clinics

SN - 1556-407X

IS - 3

ER -

Biological timekeeping

Abstract

Keywords

ASJC Scopus subject areas

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