Abstract
This review explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how biologic systems provide input to the endogenous biologic timing, and how the pacemaker influences physiology and behavior. We discuss how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of a variety of inputs. The genetics of circadian timekeeping are discussed, highlighting what is known about heritable disorders in circadian timing and how circadian genetics have been used to study timekeeping. The role of the clock in peripheral tissues is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 427-442 |
| Number of pages | 16 |
| Journal | Sleep Medicine Clinics |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2012 |
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Keywords
- Biological rhythms
- Circadian
- Sleep
- Suprachiasmatic nucleus
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuropsychology and Physiological Psychology
- Clinical Psychology
- Clinical Neurology
Cite this
Biological timekeeping. / Gillette, Martha L; Abbott, Sabra M.; Arnold, Jennifer M.
In: Sleep Medicine Clinics, Vol. 7, No. 3, 09.2012, p. 427-442.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Biological timekeeping
AU - Gillette, Martha L
AU - Abbott, Sabra M.
AU - Arnold, Jennifer M.
PY - 2012/9
Y1 - 2012/9
N2 - This review explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how biologic systems provide input to the endogenous biologic timing, and how the pacemaker influences physiology and behavior. We discuss how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of a variety of inputs. The genetics of circadian timekeeping are discussed, highlighting what is known about heritable disorders in circadian timing and how circadian genetics have been used to study timekeeping. The role of the clock in peripheral tissues is discussed.
AB - This review explains the neurobiology of circadian timekeeping, describing what is known about the master pacemaker for circadian rhythmicity, how biologic systems provide input to the endogenous biologic timing, and how the pacemaker influences physiology and behavior. We discuss how the circadian system can adapt to a changing environment by resetting the circadian clock in the face of a variety of inputs. The genetics of circadian timekeeping are discussed, highlighting what is known about heritable disorders in circadian timing and how circadian genetics have been used to study timekeeping. The role of the clock in peripheral tissues is discussed.
KW - Biological rhythms
KW - Circadian
KW - Sleep
KW - Suprachiasmatic nucleus
UR - http://www.scopus.com/inward/record.url?scp=84865707222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865707222&partnerID=8YFLogxK
U2 - 10.1016/j.jsmc.2012.06.001
DO - 10.1016/j.jsmc.2012.06.001
M3 - Review article
AN - SCOPUS:84865707222
VL - 7
SP - 427
EP - 442
JO - Sleep Medicine Clinics
JF - Sleep Medicine Clinics
SN - 1556-407X
IS - 3
ER -